Response Inhibition and Binge Drinking During Transition to University: An fMRI Study
| Autor: | Montserrat Corral, Samuel Suárez-Suárez, Jose Manuel Pérez-García, Socorro Rodríguez Holguín, Fernando Cadaveira, Sonia Doallo |
|---|---|
| Přispěvatelé: | Universidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:RC435-571
Inferior frontal gyrus Binge drinking Neuroimaging Inhibición de resposta Drinking pattern 03 medical and health sciences Neural activity 0302 clinical medicine lcsh:Psychiatry Medicine response inhibition Response inhibition IRMf Original Research Psychiatry Anterior insula Estímulos asociados a alcohol business.industry alcohol-related stimuli fMRI Neuroimaxe binge drinking 030227 psychiatry Psychiatry and Mental health Alcohol-related stimuli Motivational salience Consumo intensivo de alcohol Go/NoGo business Insula Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Psychiatry, Vol 11 (2020) Frontiers in Psychiatry Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| ISSN: | 1664-0640 |
| DOI: | 10.3389/fpsyt.2020.00535/full |
| Popis: | Background: Binge Drinking (BD), a highly prevalent drinking pattern among youth, has been linked with anomalies in inhibitory control. However, it is still not well characterized whether the neural mechanisms involved in this process are compromised in binge drinkers (BDs). Furthermore, recent findings suggest that exerting inhibitory control to alcohol-related stimuli requires an increased effort in BDs, relative to controls, but the brain regions subserving these effects have also been scarcely investigated. Here we explored the impact of BD on the pattern of neural activity mediating response inhibition and its modulation by the motivational salience of stimuli (alcohol-related content). Methods: Sixty-seven (36 females) first-year university students, classified as BDs (n = 32) or controls (n = 35), underwent fMRI as they performed an alcohol-cued Go/NoGo task in which pictures of alcoholic or non-alcoholic beverages were presented as Go or NoGo stimuli. Results: During successful inhibition trials, BDs relative to controls showed greater activity in the bilateral inferior frontal gyrus (IFG), extending to the anterior insula, a brain region usually involved in response inhibition tasks, despite the lack of behavioral differences between groups. Moreover, BDs displayed increased activity in this region restricted to the right hemisphere when inhibiting a prepotent response to alcohol-related stimuli. Conclusions: The increased neural activity in the IFG/insula during response inhibition in BDs, in the absence of behavioral impairments, could reflect a compensatory mechanism. The findings suggest that response inhibition-related activity in the right IFG/insula is modulated by the motivational salience of stimuli and highlight the role of this brain region in suppressing responses to substance-associated cues. This investigation was supported by grants from the Spanish Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan Nacional sobre Drogas (PNSD 2015/034), Ministerio de Economía y Competitividad (PSI2015-70525-P) co-funded for European Regional Development Fund and Xunta de Galicia (GRC ED431C 2017/06). SS-S was supported by a predoctoral fellowship from the Spanish Ministerio de Economía y Competitividad (BES-2016-076298). JP-G was supported by the FPU program from the Spanish Ministerio de Educación, Cultura y Deporte (FPU16/01573) SI |
| Databáze: | OpenAIRE |
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