Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China
| Autor: | Xue-Jun Cui, Qi Shi, Peizhan Chen, Chen-Guang Li, Yu-Ren Tao, Sheng Lu, Jing Wang, Bing Shu, Liang Wang, Ying-Jie Zhou, Xin-Chao Lin, Yong Zhou, Xu Wei, Bo-Lai Chen, Xiang-Yang Leng, Xing-Wen Xie, Yongjun Wang, De Liang, Yan Zhang, Hui Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Gerontology China Epidemiology Osteoporosis Traditional Chinese medicine Polymorphism Single Nucleotide Bone remodeling 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Bone Density Risk Factors Protocol cohort study Humans Multicenter Studies as Topic Medicine Longitudinal Studies Prospective Studies 030212 general & internal medicine Vitamin D Prospective cohort study Aged vitamin D gene polymorphism Aged 80 and over Bone mineral Hip Lumbar Vertebrae business.industry General Medicine Middle Aged medicine.disease osteoporosis Observational Studies as Topic Research Design Cohort Female Observational study business Osteoporotic Fractures 030217 neurology & neurosurgery Cohort study |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | IntroductionOsteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis.Methods and analysisThe China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45–80 years old and male residents aged 50–80 years old are identified through permanent resident lists. All the enrolled participants will complete questionnaires on their personal characteristics and histories. The bone mineral density of their lumbar vertebrae and left hip will be measured and serum bone metabolism parameters assessed. Polymorphisms of genes related to vitamin D metabolism and transportation will be detected, and their relationship with the risk of osteoporosis, and osteoporotic fracture, will be analysed. About 18 000 residents will be involved in the study.Ethics and disseminationThe study was approved by Institutional Ethics Board of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine (2016LCSY065). Results will be published in peer-reviewed journals. The results of this study are expected to improve the understanding of the association between polymorphisms of genes related to vitamin D metabolism and transportation and the risk of osteoporosis and osteoporotic fracture among middle-aged and older residents of China.Trial registration numberNCT02958020 |
| Databáze: | OpenAIRE |
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