Generation of a transgenic mouse line for conditional expression of human IL-6
| Autor: | Yusuke Murasawa, Ken Watanabe, Shumpei Niida, Hiroyuki Nakamura, Tomoko Hayakawa, Taiki Mori, Rina Ikai, Noboru Ogiso |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Original Transgene Gene Expression Cre recombinase Mice Transgenic Biology Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences In vivo Gene expression Animals Humans Gene Cre-loxP system IL-6 General Veterinary Interleukin-6 Promoter General Medicine Cell biology 030104 developmental biology conditional transgenic mouse Animal Science and Zoology Function (biology) |
| Zdroj: | Experimental Animals |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers. |
| Databáze: | OpenAIRE |
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