Dermal Targeting Delivery of Terbinafine Hydrochloride Using Novel Multi-Ethosomes: A New Approach to Fungal Infection Treatment
| Autor: | Shunyao Zhu, Lijun Zhang, Ting Zhang, Senlin Shi, Aikebaier Maimaiti, Xue Li, Meihong Ding |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Materials science media_common.quotation_subject Pharmacology Cinnamaldehyde law.invention Minimum inhibitory concentration chemistry.chemical_compound targeting delivery Confocal microscopy law Materials Chemistry Stratum corneum medicine terbinafine hydrochloride Candida albicans media_common Terbinafine Hydrochloride biology integumentary system cinnamaldehyde Surfaces and Interfaces biology.organism_classification In vitro Surfaces Coatings and Films medicine.anatomical_structure chemistry multi-ethosomes lcsh:TA1-2040 lcsh:Engineering (General). Civil engineering (General) antifungal |
| Zdroj: | Coatings, Vol 10, Iss 4, p 304 (2020) Coatings Volume 10 Issue 4 |
| ISSN: | 2079-6412 |
| Popis: | This research aimed to develop and evaluate a novel multi-ethosome (ME) system for the dermal delivery of terbinafine hydrochloride (TH) as a new approach to fungal infection treatment. TH-loaded MEs were successfully prepared using cinnamaldehyde as a penetration enhancer. Mean diameter of ME was found as ~100 nm with monodispersed size distribution. Drug entrapment efficiency reached up to 86% ± 1.4%. MEs exhibited excellent colloid stability and no drug leakage after 2 months of storage. In contrast to a commercial Lamisil® cream, ME significantly improved the targeting efficiency by increasing the fluidity of stratum corneum layer, revealed by attenuated total reflection Fourier transformed infrared spectroscopy (ATR-FTIR). The dermal targeting effect was visualized using confocal microscopy. Moreover, skin irritation and allergy tests showed that ME was not irritating to the skin. The improved antifungal activity of ME was proved in vitro on Candida albicans strains by minimal inhibitory concentration (MIC) assay. This study paves the way towards design of MEs for dermal fungal infection treatment. |
| Databáze: | OpenAIRE |
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