Management of isolated nonresectable liver metastases in colorectal cancer patients: a case-control study of isolated hepatic perfusion with melphalan versus systemic chemotherapy
| Autor: | Linda Mol, Miriam Koopman, Peter J. K. Kuppen, Rob A. E. M. Tollenaar, Henk H. Hartgrink, J.W.R. Nortier, Alexander L. Vahrmeijer, E.L. van Persijn van Meerten, C.J.H. van de Velde, Cornelis J. A. Punt, Hans Gelderblom, L.B.J. van Iersel |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Melphalan
Male medicine.medical_specialty Isolated hepatic perfusion Colorectal cancer medicine.medical_treatment chemotherapy colorectal cancer isolated hepatic perfusion liver metastases high-dose melphalan phase-i pharmacological evaluation fluorouracil-leucovorin oxaliplatin irinotecan infusion carcinoma resection survival Gastroenterology Translational research [ONCOL 3] Internal medicine medicine Humans Antineoplastic Agents Alkylating Chemotherapy business.industry Liver Neoplasms Cancer Hematology Middle Aged medicine.disease Chemotherapy regimen Oxaliplatin Irinotecan Oncology Case-Control Studies Chemotherapy Cancer Regional Perfusion Female business Colorectal Neoplasms medicine.drug |
| Zdroj: | Annals of Oncology, 21(8), 1662-1667 Annals of Oncology, 21, 8, pp. 1662-7 Annals of oncology, 21(8), 1662-1667. Oxford University Press Annals of Oncology, 21, 1662-7 |
| ISSN: | 0923-7534 |
| Popis: | Item does not contain fulltext BACKGROUND: To compare the median overall survival of patients with isolated nonresectable liver metastases in comparable groups of patients treated with either isolated hepatic perfusion (IHP) with melphalan or systemic chemotherapy. PATIENTS AND METHODS: Colorectal cancer patients with isolated liver metastases, who underwent IHP, were included in this study. The control group consisted of a subgroup of colorectal cancer patients with liver metastases only, who were enrolled in the randomized CApecitabine, IRinotecan, Oxaliplatin (CAIRO) phase III study. RESULTS: Ninety-nine patients were treated with IHP, and 111 patients were included in the control group. All patient characteristics were comparable except for age. Median follow-up was 78.1 months for IHP versus 54.7 months in the control group. Median overall survival was 25.0 [95% confidence interval (CI) 19.4-30.6] months for IHP and 21.7 (95% CI 19.6-23.8) months for systemic treatment and did not differ significantly (P = 0.29). Treatment-related mortality was 2% for the systemic treatment and 6% for IHP (P = 0.11). CONCLUSION: Compared with a patient group with comparable characteristics treated with systemic chemotherapy, IHP does not provide a benefit in overall survival in patients with isolated nonresectable colorectal liver metastases. Currently, the use of IHP cannot be advocated outside the scope of clinical studies. 01 augustus 2010 |
| Databáze: | OpenAIRE |
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