Association between functional polymorphisms in the flanking region of miR-143/145 and risk of papillary thyroid carcinoma: A case-control study
| Autor: | Zhihui Li, Yichao Wang, Shengliang Zhou, Wanjun Zhao, Jingqiang Zhu, Haolan Song, Tao Wei |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male China Genotype Viral Oncogene Observational Study Polymorphism Single Nucleotide polymorphism Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Asian People Polymorphism (computer science) Genetic model Medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Thyroid Neoplasms Allele Thyroid cancer Alleles business.industry General Medicine Middle Aged medicine.disease miR-145 miR-143 MicroRNAs Thyroid Cancer Papillary 030220 oncology & carcinogenesis Case-Control Studies Cancer research papillary thyroid carcinoma Female business V600E Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | MiR-143 and miR-145 were down-regulated in papillary thyroid carcinoma (PTC) involving in cell proliferation, apoptosis, migration, invasion, and epithelial to mesenchymal transition. In this study, we aimed to investigate the association between 2 functional polymorphisms (ie, rs4705342 and rs353292) in the flanking region of miR-143/145 and risk of PTC. A case-control study including 316 PTC patients and 347 controls was performed. The rs4705342 and rs353292 were genotyped by using the TaqMan allelic discrimination. The results were confirmed by DNA sequencing. For the rs4705342, a reduced risk of PTC was observed in heterozygous comparison, dominant genetic model and allele comparison (CC vs TT: adjusted OR = 0.37, 95% CI = 0.19–0.74, P = .003; CT/CC vs TT: adjusted OR = 0.64, 95% CI = 0.47–0.87, P = .005; C vs T: adjusted OR = 0.66, 95% CI = 0.52–0.85, P = .001, respectively). No significant difference was found in the genotypic distributions of the rs353292 between cases and controls. These findings indicate that the rs4705342 in the flanking region of miR-143/145 may be a protective factor against the occurrence of PTC. Further study is therefore required to investigate the correlation between the genotype and V-raf murine sarcoma viral oncogene homolog B1 V600E, rat sarcoma viral oncogene homolog mutations, rearranged in transformation/PTC1 and rearranged in transformation/PTC3. |
| Databáze: | OpenAIRE |
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