Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing
| Autor: | Anirudh B. Acharya, Srinath Thakur, Sai M. Surve |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Simvastatin Atorvastatin Dentistry environment and public health Root Planing Scaling and root planing Interleukin-1alpha medicine Humans Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Periodontitis business.industry Dental scaling Interleukin Administration Buccal Gingival Crevicular Fluid Middle Aged medicine.disease Chronic periodontitis Adjunct Treatment Outcome Case-Control Studies Chronic Disease Dental Scaling Hydroxymethylglutaryl-CoA Reductase Inhibitors business Gels medicine.drug |
| Zdroj: | Drug metabolism and personalized therapy. 30(4) |
| ISSN: | 2363-8915 |
| Popis: | The current understanding of the pathogenesis of periodontal disease has resulted in adjunctive use of various pharmacologic agents in periodontal therapy. The objective of this investigation was to assess the efficacy of atorvastatin and simvastatin (because of their pleiotropic properties) as an adjunct to dental scaling and root planing (SRP) by local delivery, i.e. placing them subgingivally, in the treatment of chronic periodontitis.Local delivery systems for atorvastatin and simvastatin were prepared in sodium alginate suspension to be administered with calcium chloride solution. Patients diagnosed with chronic periodontitis were grouped as group 1, receiving SRP only (control), group 2, receiving SRP with subgingival delivery of 1.2% simvastatin, and group 3, receiving SRP with subgingival delivery of 1.2% atorvastatin. Clinical parameters and interleukin (IL) 1α levels in the gingival crevicular fluid (GCF) were assessed.All three groups showed significant reductions in clinical parameters and IL-1α levels in the GCF (pSubgingivally delivered atorvastatin and simvastatin as an adjunct to SRP is efficacious but did not demonstrate any added benefit as compared with SRP alone. |
| Databáze: | OpenAIRE |
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