Marine microbial L-glutaminase: from pharmaceutical to food industry
Autor: | Muhammad Sohail, Saeid Tamadoni Jahromi, Mojgan Khodadadi, Noora Barzkar, Reza Nahavandi |
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Rok vydání: | 2021 |
Předmět: |
0106 biological sciences
0303 health sciences L-Glutaminase Food industry business.industry Glutamine Microorganism Fungi General Medicine 01 natural sciences Applied Microbiology and Biotechnology Biotechnology 03 medical and health sciences Glutaminase Pharmaceutical Preparations 010608 biotechnology Food Industry Environmental science Prospective Studies business 030304 developmental biology |
Zdroj: | Applied Microbiology and Biotechnology. 105:4453-4466 |
ISSN: | 1432-0614 0175-7598 |
Popis: | Deamination of L-glutamine to glutamic acid with the concomitant release of ammonia by the activity of L-glutaminase (L-glutamine amidohydrolase EC 3.5.1.2) is a unique reaction that also finds potential applications in different sectors ranging from therapeutics to food industry. Owing to its cost-effectiveness, rapidity, and compatibility with downstream processes, microbial production of L-glutaminase is preferred over the production by other sources. Marine microorganisms including bacteria, yeasts, and moulds have manifested remarkable capacity to produce L-glutaminase and, therefore, are considered as prospective candidates for large-scale production of this enzyme. The main focus of this article is to provide an overview of L-glutaminase producing marine microorganisms, to discuss strategies used for the lab- and large-scale production of these enzyme and to review the application of L-glutaminase from marine sources so that the future prospects can be understood. KEY POINTS: • L-glutaminase has potential applications in different sectors ranging from therapeutics to food industry • Marine microorganisms are considered as prospective candidates for large-scale production of L-glutaminase • Marine microbial L-glutaminase have great potential in therapeutics and in the food industry. |
Databáze: | OpenAIRE |
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