The Dutch Transplantation in Vasculitis (DUTRAVAS) Study: Outcome of Renal Transplantation in Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis
| Autor: | Eric J. Steenbergen, Carine J. Peutz-Kootstra, Iris Noorlander, Ingeborg M. Bajema, Marcory C. R. F. van Dijk, Stefan P Berger, Marlies E.J. Reinders, Chinar Rahmattulla, Arda Göçeroğlu, Lorraine Harper, Annelies E. Berden, Mark A. Little, Roel Goldschmeding, Anoek A. E. de Joode, Ron Wolterbeek, Maarten H. L. Christiaans, Luuk B. Hilbrands, Arjan D. van Zuilen, E. Christiaan Hagen, Jan A. Bruijn |
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| Přispěvatelé: | MUMC+: DA Pat Pathologie (9), RS: CARIM - R3.06 - The vulnerable plaque: makers and markers, Pathologie, Interne Geneeskunde, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, MUMC+: MA Nefrologie (9), Internal Medicine |
| Rok vydání: | 2015 |
| Předmět: |
Male
ANCA-ASSOCIATED VASCULITIS Time Factors Biopsy 030232 urology & nephrology Kaplan-Meier Estimate 030230 surgery Hospitals University 0302 clinical medicine Glomerulonephritis Recurrence Risk Factors Registries Kidney transplantation Netherlands Kidney Graft Survival Middle Aged Allografts Hospitals Multicenter Study surgical procedures operative medicine.anatomical_structure Treatment Outcome REMISSION-INDUCTION RELAPSE RATE Female Vasculitis Systemic vasculitis Adult ALLOGRAFT PATHOLOGY medicine.medical_specialty Adolescent UNITED-STATES Observational Study SYSTEMIC VASCULITIS Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis SMALL-VESSEL VASCULITIS CLASSIFICATION 03 medical and health sciences WEGENERS-GRANULOMATOSIS Predictive Value of Tests Internal medicine Journal Article medicine Humans Anti-neutrophil cytoplasmic antibody Aged Proportional Hazards Models Retrospective Studies GRAFT-SURVIVAL University Transplantation Proportional hazards model business.industry Retrospective cohort study medicine.disease Kidney Transplantation Surgery Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] Multivariate Analysis Renal disorders Radboud Institute for Health Sciences [Radboudumc 11] business |
| Zdroj: | Transplantation, 100(4), 916. Lippincott Williams and Wilkins Transplantation, 100(4), 916-924. LIPPINCOTT WILLIAMS & WILKINS Transplantation, 100, 916-24 Transplantation, 100, 4, pp. 916-24 Transplantation, 100(4), 916-924. Lippincott Williams & Wilkins Transplantation, 100(4), 916-924 |
| ISSN: | 1534-6080 0041-1337 |
| Popis: | Item does not contain fulltext BACKGROUND: Data on the outcome of renal transplantation in antineutrophil cytoplasmic antibody-associated glomerulonephritis (AAGN) patients are still limited. In particular, how disease recurrence in the renal allograft defines graft outcome is largely unknown. Therefore, we conducted a multicenter observational clinical and histopathological study to establish recurrence rate of AAGN in the allograft and the impact of recurrence on allograft survival. METHODS: Using the nationwide Dutch Pathology Registry (PALGA), we retrospectively collected clinical and histopathological data of consecutive AAGN patients who had developed end-stage renal failure and received a kidney allograft in 1 of 6 Dutch university hospitals between 1984 and 2011. Transplant biopsies were scored using the Banff '09 classification. Renal disease recurrence was scored using the histopathological classification of AAGN. RESULTS: The posttransplantation recurrence rate of AAGN was 2.8% per patient year, accumulating to recurrence in a total of 11 of 110 AAGN patients within the first 5 years after transplantation. Four of these 11 patients lost their graft, with 1-year and 5-year graft survival rates of 94.5% and 82.8%, respectively. By multivariate analysis, AAGN recurrence was independently associated with subsequent graft loss. CONCLUSIONS: In this study in 110 Dutch patients, the recurrence rate of AAGN within 5 years after kidney transplantation appeared slightly higher than in previous reports. Moreover, recurrence of AAGN contributed independently to kidney allograft loss, emphasizing the importance of clinical vigilance, because early treatment might be critical to rescuing the allograft. |
| Databáze: | OpenAIRE |
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