Daily oscillation of cognitive factors is modified in the temporal cortex of an amyloid β(1-42)-induced rat model of Alzheimer’s disease
| Autor: | Carina Ledezma, Andrea Castro, Lorena S. Navigatore-Fonzo, Ana Cecilia Anzulovich, Cinthia Coria-Lucero, Silvia Marcela Delgado |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Apolipoprotein E medicine.medical_specialty Tropomyosin receptor kinase B Pathogenesis 03 medical and health sciences Cognition 0302 clinical medicine Alzheimer Disease Internal medicine Extracellular medicine Animals Receptor trkB Cognitive Dysfunction Circadian rhythm Cognitive deficit Temporal cortex Amyloid beta-Peptides Chemistry Brain-Derived Neurotrophic Factor General Neuroscience medicine.disease Peptide Fragments Temporal Lobe Circadian Rhythm Rats 030104 developmental biology Endocrinology Alzheimer's disease medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Brain Research Bulletin. 170:106-114 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2021.01.014 |
| Popis: | Alzheimer's disease (AD) is a devastating disease characterized by loss of synapses and neurons in the elderly. Accumulation of the β-amyloid peptide (Aβ) in the brain is thought to be central to the pathogenesis of AD. ApoE plays a key role in normal and physiological clearance of Aß, since it facilitates the peptide intra- and extracellular proteolytic degradation. Besides the cognitive deficit, AD patients also show alterations in their circadian rhythms. The objective of this study was to investigate the effects of an i.c.v. injection of Aβ (1-42) peptide on the 24 h rhythms of Apo E, BMAL1, RORα, Bdnf and trkB mRNA and Aβ levels in the rat temporal cortex. We found that an i.c.v. injection of Aβ aggregates phase shifts daily Bdnf expression as well as Apo E, BMAL1, RORα, Aβ and decreased the mesor of TrkB rhythms. Thus, elevated Aβ peptide levels might modify the temporal patterns of cognition-related factors, probably; by affecting the clock factors rhythms as well as in the 24 h rhythms of Apo E. |
| Databáze: | OpenAIRE |
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