Survival After a Lethal Dose of Arsenic Trioxide
| Autor: | Jean-François Heilier, Arnold Michels, Agnes Meulemans, Barbara Vantroyen, Jean-Pierre Buchet, Steven Vanderschueren, Marc Sabbe, Vincent Haufroid |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Radiography Abdominal medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment Antidotes Poison control Suicide Attempted Arsenicum album Sodium Chloride Toxicology Gastroenterology Arsenicals chemistry.chemical_compound Arsenic Trioxide Internal medicine medicine Humans Arsenic trioxide Therapeutic Irrigation Antidote Chelating Agents medicine.diagnostic_test Electromyography business.industry Lethal dose Oxides Surgery Sodium Bicarbonate chemistry Charcoal Toxicity Vomiting Female medicine.symptom Liver function tests business |
| Zdroj: | Journal of Toxicology: Clinical Toxicology. 42:889-895 |
| ISSN: | 0731-3810 |
| Popis: | A case of a 27-year-old woman who ingested 9000 mg arsenic trioxide (As2O3) is reported. Classical symptoms of an acute arsenicum (As) poisoning such as gastrointestinal cramps, vomiting, diarrhea, ECG changes and disturbed liver function tests were observed. The absorption of the ingested As was minimalized by a continuous gastric irrigation with highly concentrated NaHCO3 and intestinal cleansing with NaHCO3 and polyethyleneglycol was performed. Forced diuresis, BAL (2,3-dimercaptopropanol) and DMSA (meso-2,3-dimercaptosuccinic acid) were started and therapy to enhance the formation of methylated As derivatives, which are potentially less toxic and which can be excreted more easily, was then administered. The patient survived this massive dose of ingested inorganic As with only polyneuropathy one year later. |
| Databáze: | OpenAIRE |
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