Quantifying the effect of isoflurane on mivacurium infusion requirements
| Autor: | M. Kansanaho, Klaus T. Olkkola |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_treatment Neuromuscular Junction Nitrous Oxide Drug Administration Schedule Fentanyl 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 030202 anesthesiology Medicine Intubation Humans In patient Aged Dose-Response Relationship Drug Isoflurane business.industry 030208 emergency & critical care medicine Drug Synergism Nitrous oxide Middle Aged Isoquinolines 3. Good health Mivacurium Anesthesiology and Pain Medicine chemistry Anesthesia Pharmacodynamics Anesthetics Inhalation Female business Oxygen mixture Surgical patients medicine.drug Neuromuscular Nondepolarizing Agents |
| Zdroj: | Anaesthesia. 51(2) |
| ISSN: | 0003-2409 |
| Popis: | Summary We evaluated the effect of different concentrations of isoflurane in a nitrous oxide/oxygen mixture on the infusion requirements of mivacurium in 60 adult surgical patients. Anaesthesia was induced with thiopentone andfentanyl, and intubation was facilitated with mivacurium 0.15mg.kg-1. The patients were randomly assigned to one of four study groups. The control group received nitrous oxide in oxygen (2:1) anaesthesia supplemented with fentanyl. In the other groups, isoflurane was administered at different end-tidal concentrations: 0.29%, 0.58% and 1.15%, corresponding to 0.25, 0.5 and 1.0 MAC of isoflurane, respectively. Neuromuscular block was maintained at 95% with a computer-controlled infusion of mivacurium and monitored with electromyography. The mean (SD) steady-state infusion requirements of mivacurium in patients receiving nitrous oxide-fentanyl anaesthesia or isoflurane 0.25–0.5 MAC were similar, ranging from 6.1 (2.2) to 5.1 (2.1) μg.kg-1.min-1. Isoflurane 1.0 MAC reduced mivacurium infusion requirements by 32% (p < 0.01). Interindividual differences in mivacurium infusion requirements were large. |
| Databáze: | OpenAIRE |
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