Causal Modeling of the Glucose-Insulin System in Type-I Diabetic Patients
Autor: | J. Fernandez, N. Aguilar, R. Fernandez de Canete, J. C. Ramos-Diaz |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: | |
Zdroj: | RIUMA. Repositorio Institucional de la Universidad de Málaga instname |
Popis: | In this paper, a simulation model of the glucose-insulin system for a patient undergoing diabetes Type 1 is developed by using a causal modeling approach under system dynamics. The OpenModelica simulation environment has been employed to build the so called causal model, while the glucose-insulin model parameters were adjusted to fit recorded mean data of a diabetic patient database. Model results under different conditions of a three-meal glucose and exogenous insulin ingestion patterns have been obtained. This simulation model can be useful to evaluate glucose-insulin performance in several circumstances, including insulin infusion algorithms in open-loop and decision support systems in closed-loop. {"references":["J. D. Sterman, \"System dynamics modeling: Tools for learning in a complex world\". California management review. 43 (4), 2001, 8–25.","D. M. Rubin, C. L. Richards, P. A. Keene, J. E. Paiker, A. R. Gray, R. F. Herron, M. J. Russell, B. Wigdorowitz, \"System dynamics in medical education: a tool for life\", Adv Health Sci Educ Theory Pract., vol. 17(2), 2012, pp. 203-210.","G. Li, J. Gao, F. Chen \"Construction of causality diagram model for diagnostics\", Reliability and Maintainability Symposium, 2008. RAMS 2008, pp. 125-130.","Y. Okuda, E.O. Bryson, S. De Maria, L. Jacobson, J. Quinones , B. Shen, A.I. Levine, \"The utility of simulation in medical education: what is the evidence?\", Mt Sinai J Med, Vol. 76(4), 2009, pp. 330-343.","J.A. Gordon, J. Pawlowski, \"Education on-demand: the development of a simulator-based medical education service\", Acad Med., vol. 77(7), 2002, pp. 751-752.","World Health Organization. Global report on diabetes, Geneva, 2016.","C. Dallaman, D.M. Raimondo, R.A. Rizza, C. Cobelli, c. \"GIM, Simulation Software of Meal Glucose-Insulin Model\", J. Diab Sci and Technology, vol. 1(3), 2007, pp. 323-330.","P. Fritzson. Principles of Object-oriented Modeling and Simulation with Modelica 2.1: Wiley-IEEE Press, 2003.","A. Makroglou, J. Li, Y. Kuang \"Mathematical models and software tools for the glucose-insulin regulatory system and diabetes: An overview\", Applied Numerical Mathematics vol. 56, pp. 559–573.\n[10]\tB.R. Hipszer. A type 1 diabetic model. M. A. Thesis, Submitted to the Faculty of Drexel University, 2001.\n[11]\tG. Coyle, \"Qualitative and quantitative modelling in system dynamics: some research questions\", Sys Dyn Rev, vol. 16(3), 2000, pp. 225-244.\n[12]\tF. Cellier, \"World3 in Modelica: Creating System Dynamics Models in the Modelica Framework\", in: Proceedings of the 7th International Modelica Conference 2008, pp. 393-400."]} |
Databáze: | OpenAIRE |
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