Liquid Biopsy: It's the Bloody Truth!
| Autor: | Andrew J. Armstrong, Nathan M. Hawkey |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty MEDLINE Article Circulating Tumor DNA 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Liquid biopsy Aged Aged 80 and over BRCA2 Protein BRCA1 Protein business.industry Genomics Middle Aged medicine.disease Bloody Prostatic Neoplasms Castration-Resistant 030104 developmental biology Receptors Androgen Circulating tumor DNA 030220 oncology & carcinogenesis Mutation Treatment decision making business |
| Zdroj: | Clin Cancer Res |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-21-0531 |
| Popis: | Comprehensive genomic profiling (CGP) is of increasing value for patients with metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to bone, making tissue biopsies challenging to obtain. We hypothesized CGP of cell-free circulating tumor DNA (ctDNA) could offer a minimally invasive alternative to detect targetable genomic alterations (GA) that inform clinical care.Using plasma from 3,334 patients with mCRPC (including 1,674 screening samples from TRITON2/3), we evaluated the landscape of GAs detected in ctDNA and assessed concordance with tissue-based CGP.A total of 3,129 patients (94%) had detectable ctDNA with a median ctDNA fraction of 7.5%;Genomic analysis of ctDNA from patients with mCRPC recapitulates the genomic landscape detected in tissue biopsies, with a high level of agreement in detection of |
| Databáze: | OpenAIRE |
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