Sex-based differences in bacterial meningitis in adults: Epidemiology, clinical features, and therapeutic outcomes
| Autor: | Ben-C. Cheng, Cheng-H. Lu, Dong-Y. Hsieh, Yun-R. Lai, Chia-Y. Lien, Chia-T. Kung, Wen-N. Chang, Chih-C. Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Diabetic ketoacidosis Traumatic brain injury Epidemiology Infectious and parasitic diseases RC109-216 Meningitis Bacterial Internal medicine Case fatality rate medicine Humans Brain abscess Retrospective Studies Outcome Cross Infection Sex-based difference business.industry Incidence (epidemiology) Public Health Environmental and Occupational Health Retrospective cohort study Clinical features General Medicine medicine.disease Klebsiella Infections Treatment Outcome Infectious Diseases Culture-proven bacterial meningitis Concomitant Female Public aspects of medicine RA1-1270 business |
| Zdroj: | Journal of Infection and Public Health, Vol 14, Iss 9, Pp 1218-1225 (2021) |
| ISSN: | 1876-0341 |
| Popis: | Background: To investigate the sex-based differences in clinical features, causative pathogens, and outcomes of hospital-based culture-proven adult bacterial meningitis. Objective: This retrospective study enrolled 621 patients at a tertiary medical center. To compare changes over time, the presentation of disease among the enrolled patients was divided into two equal time periods: the first study period (1986–2002) and the second study period (2003–2019). Results: Of the 621 patients enrolled in this study, 396 were males and 225 were females. The overall case fatality rate was 30.4% with 30.1% and 31.1% in males and females, respectively. Regarding the causative pathogens, there was a rising incidence of coagulase-negative staphylococcal infections and a decreasing incidence of Klebsiella pneumoniae infection in both male and female in the second study period. The prevalence of patients with nosocomial infection in a postneurosurgical state were 41.9% (68/162) in the first study period and 58.1% (94/162) in the second study period in male group, and 34.8% (32/92) in the first study period and 65.2% (60/92) in the second study period in female group, respectively. Significant factors between the sexes difference included age (P = 0.004), traumatic brain injury (P = 0.01), alcoholism (P < 0.001), brain tumor (P < 0.001), systemic lupus erythematosus (SLE) (P = 0.004), presence of diabetic ketoacidosis/hyperglycemic hyperosmolar state (P = 0.033), brain abscess (P = 0.042), and total protein (P = 0.002) and white blood cell count (P = 0.036) of cerebrospinal fluid data. Conclusion: Our study revealed an increase in the number of patients with nosocomial infection with a postneurosurgical state in both male and female in the second study period. Males were younger and frequently presented with a history of head trauma and alcoholism with concomitant brain abscesses while females presented with SLE and brain tumor. The therapeutic outcome did not show differences between the sexes. |
| Databáze: | OpenAIRE |
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