Blood-borne non-A, non-B hepatitis: lack of infectivity of feces from chimpanzees infected with a strain producing cytoplasmic tubular alterations
| Autor: | Tellervo Huima, M. C. van den Ende, Alfred M. Prince, Betsy Brotman, Linda Richardson |
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| Rok vydání: | 1983 |
| Předmět: |
Infectivity
Hepatitis Strain (chemistry) Hepatitis Viral Human Inoculation Hepatitis C Biology medicine.disease Virology Vaccination Feces Microscopy Electron Infectious Diseases Alanine transaminase Liver Hepatitis Viruses biology.protein medicine Immunology and Allergy Animals Humans Female Cytoskeleton |
| Zdroj: | The Journal of infectious diseases. 147(3) |
| ISSN: | 0022-1899 |
| Popis: | Fecal and serum samples from a chimpanzee with acute-phase, blood-borne non-A, non-B hepatitis were administered to four chimpanzees. Fecal material given either intravenously or orally did not result in abnormal levels of alanine aminotransferase or the occurrence of ultrastructural alterations in hepatocellular cytoplasm characteristic of non-A, non-B hepatitis during a one-year period of follow-up. Definite non-A, nonB hepatitis was later demonstrated in two of these animals four weeks after inoculation of acute-phase serum. Thus, feces do not appear to transmit this human strain of blood-borne non-A, non-B hepatitis. The epidemiology of blood-borne non-A, non-B (NANB) hepatitis seen in Europe and North |
| Databáze: | OpenAIRE |
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