Effect of Sfrp5 on Cytokine Release and Insulin Action in Primary Human Adipocytes and Skeletal Muscle Cells
| Autor: | Christian Herder, Maren Carstensen, Michael Roden, Pia Fahlbusch, K. Röhrig, Claudia Wiza, D. Margriet Ouwens |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Anatomy and Physiology medicine.medical_treatment Glucose uptake lcsh:Medicine Mice Endocrinology Insulin Signaling Cascade Molecular Cell Biology Adipocytes Insulin lcsh:Science Cells Cultured Multidisciplinary biology Chemistry Middle Aged Signaling Cascades Cytokine Phosphorylation Medicine Cytokines Female Research Article Signal Transduction Adult medicine.medical_specialty Adolescent Adipokine Endocrine System Wnt-5a Protein Young Adult Internal medicine Proto-Oncogene Proteins medicine Animals Humans Eye Proteins Muscle Skeletal Biology Adaptor Proteins Signal Transducing Diabetic Endocrinology Inflammation Muscle Cells Adiponectin Endocrine Physiology Tumor Necrosis Factor-alpha lcsh:R Membrane Proteins Diabetes Mellitus Type 2 Wnt Proteins Insulin receptor Glucose biology.protein lcsh:Q Cytokine secretion |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 1, p e85906 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Secreted frizzled-related protein 5 (Sfrp5) is an adipokine with anti-inflammatory and insulin-sensitizing properties in mice. However, the mechanism of Sfrp5 action, especially in humans, is largely unknown. Therefore, cytokine release and insulin signaling were analyzed to investigate the impact of Sfrp5 on inflammation and insulin signaling in primary human adipocytes and skeletal muscle cells (hSkMC). Sfrp5 neither affected interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1) and adiponectin release from human adipocytes, nor IL-6 and IL-8 release from hSkMC. In tumor necrosis factor (TNF) α-treated adipocytes, Sfrp5 reduced IL-6 release by 49% (p |
| Databáze: | OpenAIRE |
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