Six new prenylated acetophenone derivatives from the leaves of Acronychia oligophlebia
| Autor: | Yu-Bo Zhang, Xiang-Qiang Zhang, Yao-Lan Li, Jianwei Jiang, Guo-Cai Wang, Xian Yang, Zhong-Nan Wu |
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| Rok vydání: | 2015 |
| Předmět: |
Prenylation
Pharmacology Molecular Structure biology Stereochemistry Acetophenones General Medicine biology.organism_classification Antineoplastic Agents Phytogenic Acronychia Plant Leaves Inhibitory Concentration 50 chemistry.chemical_compound chemistry Drug Discovery MCF-7 Cells Ic50 values Humans Organic chemistry Oligophlebia Rutaceae Two-dimensional nuclear magnetic resonance spectroscopy Acetophenone |
| Zdroj: | Fitoterapia. 105:156-159 |
| ISSN: | 0367-326X |
| Popis: | Six new prenylated acetophenone derivatives were isolated from the leaves of Acronychia oligophlebia. The chemical structures of them were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The cytotoxic activity of the isolates was evaluated against MCF-7 cells. Among these compounds, 2 and 6 exhibited mild cytotoxic activity with IC50 values of 33.5 and 25.6 μM, respectively. |
| Databáze: | OpenAIRE |
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