Metabolic disturbances and cardiovascular risk factors in obese children with vitamin D deficiency
| Autor: | B. Dündar, F. Yasar, A. Rahmi Bakiler, Murat Anil, Mehmet Helvaci, R. Colak, O. Pirgon |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatric Obesity medicine.medical_specialty Ambulatory blood pressure Adolescent vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Insulin resistance 030225 pediatrics Internal medicine Prevalence medicine Vitamin D and neurology Humans Glucose homeostasis Child Dyslipidemias Metabolic Syndrome business.industry Vitamin D Deficiency medicine.disease Endocrinology Intima-media thickness Heart Disease Risk Factors Case-Control Studies Hyperglycemia Pediatrics Perinatology and Child Health Female Insulin Resistance business Body mass index Dyslipidemia |
| Popis: | The prevalence of obesity among children and adolescents has been rapidly increasing in recent years. Obese individuals are at risk of vitamin D deficiency. The aim of this study was to investigate the relationship between vitamin D deficiency and anthropometric measurements, cardiovascular risk factors, and glucose homeostasis in obese children.Between June 2011 and January 2012, 40 obese and 30 non-obese children (between 7 and 14 years of age) were evaluated at Tepecik Training and Research Hospital. The following characteristics were recorded: height; weight; body mass index (BMI); total body fat content; fasting glucose, insulin, and lipid levels; basic biochemical parameters; complete blood count; bilateral carotid intima media thickness; liver ultrasound results; and left ventricular wall thickness were recorded. 25-hydroxy (OH) vitamin D levels were measured from serum.The serum 25(OH) vitamin D level was low in 45 children (64.3%). The 24-h ambulatory blood pressure measurements, carotid intima-media thickness, and the prevalence of 25(OH) vitamin D deficiency were different between obese and non-obese children (P0.05). The incidence of dyslipidemia was not statistically different between obese and non-obese children (P0.05). Plasma 25(OH) vitamin D concentrations were negatively correlated with age, BMI, total body fat content, 24-h ambulatory blood pressure, and carotid intima-media thickness (P0.05). Plasma 25(OH) vitamin D levels were not correlated with fasting plasma glucose, HOMA-IR, triglycerides, total cholesterol, low-density cholesterol, and high-density cholesterol (P0.05).Vitamin D deficiency is more prevalent in obese children. Serum 25(OH)vitamin D was significantly associated with several cardiometabolic risk factors. There was no relationship between abnormal glucose homeostasis and dyslipidemia with vitamin D deficiency in obese children. |
| Databáze: | OpenAIRE |
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