Current Research Provides Insight into the Biological Basis and Diagnostic Potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Autor:	Warren P. Tate, Angus Mackay, Eiren Sweetman, Alex Noble, Rosamund Vallings, Margaret Ryan, Amber Helliwell, Christina D. Edgar
Rok vydání:	2019
Předmět:	circadian rhythm musculoskeletal diseases 0301 basic medicine medicine.medical_specialty diagnostic biomarker Encephalomyelitis Clinical Biochemistry Institute of medicine Disease chronic fatigue syndrome Viral infection neuro-inflammation 03 medical and health sciences 0302 clinical medicine medicine Chronic fatigue syndrome inflammation and immunity Intensive care medicine lcsh:R5-920 business.industry virus diseases Diagnostic test medicine.disease Molecular biomarkers nervous system diseases 3. Good health myalgic encephalomyelitis mitochondria 030104 developmental biology Commentary Etiology lcsh:Medicine (General) business metabolism 030217 neurology & neurosurgery
Zdroj:	Diagnostics, Vol 9, Iss 3, p 73 (2019) Diagnostics
ISSN:	2075-4418
Popis:	Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe fatigue illness that occurs most commonly following a viral infection, but other physiological triggers are also implicated. It has a profound long-term impact on the life of the affected person. ME/CFS is diagnosed primarily by the exclusion of other fatigue illnesses, but the availability of multiple case definitions for ME/CFS has complicated diagnosis for clinicians. There has been ongoing controversy over the nature of ME/CFS, but a recent detailed report from the Institute of Medicine (Academy of Sciences, USA) concluded that ME/CFS is a medical, not psychiatric illness. Importantly, aspects of the biological basis of the ongoing disease have been revealed over the last 2–3 years that promise new leads towards an effective clinical diagnostic test that may have a general application. Our detailed molecular studies with a preclinical study of ME/CFS patients, along with the complementary research of others, have reported an elevation of inflammatory and immune processes, ongoing neuro-inflammation, and decreases in general metabolism and mitochondrial function for energy production in ME/CFS, which contribute to the ongoing remitting/relapsing etiology of the illness. These biological changes have generated potential molecular biomarkers for use in diagnostic ME/CFS testing.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7ab2ae5e45f67bbe60d6f3b656a4e0 https://doi.org/10.3390/diagnostics9030073 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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