Pretreatment plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) in patients with operable cervical cancer: Influence of surgical-pathological stage, tumor size, histologic type, and lymph node status
| Autor: | Virgilio Facchini, R Marrai, Piero Fioretti, Barbara del Bravo, U Baicchi, Pier Vittorio Fosella, Angiolo Gadducci |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Fibrinopeptide A Urology Uterine Cervical Neoplasms Adenocarcinoma Hysterectomy Fibrin Fibrinogen Degradation Products Von Willebrand factor von Willebrand Factor D-dimer medicine Humans In patient Radical Hysterectomy Stage (cooking) Lymph node Pathological Aged Neoplasm Staging Gynecology Cervical cancer Analysis of Variance biology business.industry Obstetrics and Gynecology General Medicine Plasma levels Middle Aged medicine.disease medicine.anatomical_structure Oncology In utero Lymphatic Metastasis Carcinoma Squamous Cell biology.protein Female business |
| Zdroj: | International Journal of Gynecology & Obstetrics. 45:72-72 |
| ISSN: | 0020-7292 |
| DOI: | 10.1016/0020-7292(94)90777-3 |
| Popis: | The preoperative plasma levels of fibrinopeptide A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) were measured in 38 patients with cervical cancer undergoing radical hysterectomy with pelvic lymphadenectomy. The surgical-pathological stage of disease was Ib in 17 patients, IIa in 9 patients, and IIb in 12 patients. The tumor size wasor = 4 cm in 20 patients and4 cm in 18 patients. The histologic type was squamous cell carcinoma in 32 patients and adenocarcinoma in 6 patients. Positive pelvic lymph nodes were found in 10 patients. When compared to controls, FPA, DD, and vWF levels were significantly raised in patients with surgical-pathological stage IIb disease but not in patients with stage Ib or IIa disease. The values of FPA, DD, and vWF were related to surgical-pathological stage (stage IIb vs stage Ib-IIa: P0.005, P0.001, and P0.001, respectively) and tumor size (4 cm vsor = 4 cm: P0.05, P0.005, and P0.02, respectively), but not to histologic type. vWF values were also related to lymph node status (positive vs negative lymph nodes: P0.02). FPA and DD levels were higher in patients with positive lymph nodes than in patients with negative lymph nodes, but the difference did not reach the statistical significance even due to the small number of patients involved. In conclusion, increased fibrin production and degradation seem to occur in patients with stage IIb cervical cancer. The biological meaning of this hemostasis activation deserves further investigation. |
| Databáze: | OpenAIRE |
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