Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease

Autor:	Alessia Omenetti, Cynthia D. Guy, Anna Mae Diehl, Nagy A. Youssef, Alastair D. Smith, Martin Binks, Manal F. Abdelmalek, Ayako Suzuki
Rok vydání:	2013
Předmět:	Adult Male medicine.medical_specialty Anxiety Pharmacotherapy Non-alcoholic Fatty Liver Disease Internal medicine Surveys and Questionnaires Nonalcoholic fatty liver disease medicine North Carolina Odds Ratio Humans Depression (differential diagnoses) Subclinical infection Likelihood Functions Hepatology business.industry Depression Confounding Odds ratio Middle Aged medicine.disease digestive system diseases Antidepressive Agents Fatty Liver Endocrinology Cross-Sectional Studies Logistic Models Antidepressant Female medicine.symptom business
Zdroj:	Liver international : official journal of the International Association for the Study of the Liver. 33(7)
ISSN:	1478-3231
Popis:	Background Depression and anxiety are common in patients with nonalcoholic fatty liver disease (NAFLD). However, their associations with histological severity of NAFLD are unknown. Aim This study examined the association(s) of depression, anxiety and antidepressant pharmacotherapy with severity of histological features in patients with NAFLD. Methods We analysed 567 patients with biopsy-proven NAFLD enrolled in the Duke NAFLD Clinical Database. Depressive and anxiety symptoms were assessed using the Hospital Anxiety & Depression Scale (HADS). The associations of depression and anxiety with severity of histological features of NAFLD were analysed using multiple logistic (or ordinal logistic) regression models with and without adjusting for confounding factors. Result Subclinical and clinical depression was noted in 53% and 14% of patients respectively. Subclinical and clinical anxiety was noted in 45% and 25% of patients respectively. After adjusting for confounders, depression was significantly associated with more severe hepatocyte ballooning in a dose-dependent manner (likelihood ratio test, P = 0.0201); adjusted cumulative odds ratio (COR) of subclinical and clinical depression for having a higher grade of hepatocyte ballooning were 2.1 [95% CI, 1.0, 4.4] and 3.6 [95% CI, 1.4, 8.8]. Conclusions In patients with NAFLD, depression was associated with more severe hepatocyte ballooning. Further investigation exploring pathobiological mechanisms underlying the observed associations and potential effects of antidepressant pharmacotherapy on NAFLD liver histology is warranted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7883c008cd27f88942f96002bd232e https://pubmed.ncbi.nlm.nih.gov/23560860 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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