Analysis of the factors affecting the safety of robotic stereotactic body radiation therapy for hepatocellular carcinoma patients
| Autor: | Zhi Yong Yuan, Yong Chun Song, Ping Wang, Xian Zhi Zhao, Ting Shi Su, Xiao Jie Liu, Huo Jun Zhang, Ping Liang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
adverse hepatic reactions Stereotactic body radiation therapy Liver volume CyberKnife robotic stereotactic body radiation therapy OncoTargets and Therapy 03 medical and health sciences 0302 clinical medicine Cyberknife Medicine Pharmacology (medical) Related factors business.industry Child–Turcotte–Pugh class hepatocellular carcinoma medicine.disease Gross tumor volume Oncology Clinical Trial Report 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology Radiology Liver function business |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Xiaojie Liu,1,* Yongchun Song,1,* Ping Liang,2 Tingshi Su,2 Huojun Zhang,3 Xianzhi Zhao,3 Zhiyong Yuan,1 Ping Wang1 1Department of Radiotherapy,Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, 2Cyberknife Center, Ruikang Hospital, Guangxi Traditional Chinese Medical University, Nanning, 3Department of Radiotherapy, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed equally to this work Objective: The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors.Methods: A total of 74 HCC patients with Child–Turcotte–Pugh (CTP) ClassA were included in a multi-institutional, single-arm Phase II trial (NCT 02363218) between February 2013 and August 2016. All patients received SBRT treatment at a dose of 45Gy/3f. The liver function was compared before and after SBRT treatment by the analysis of adverse hepatic reactions and changes in CTP classification.Results: After SBRT treatment, eight patients presented with decreases in CTP classification and 13 patients presented with ≥grade 2 hepatic adverse reactions. For patients presenting with ≥grade 2 hepatic adverse reactions, the total liver volume of ≤1,162mL and a normal liver volume (total liver volume – gross tumor volume [GTV]) of ≤1,148mL were found to be independent risk factors and statistically significant (P1,162mL and a normal liver volume >1,148mL should be ensured to improve therapeutic safety. Keywords: hepatocellular carcinoma, robotic stereotactic body radiation therapy, CyberKnife, Child–Turcotte–Pugh class, adverse hepatic reactions |
| Databáze: | OpenAIRE |
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