Seroepidemiologic survey of epidemic cholera in Haiti to assess spectrum of illness and risk factors for severe disease
| Autor: | Brendan R, Jackson, Deborah F, Talkington, James M, Pruckler, M D Bernadette, Fouché, Elsie, Lafosse, Benjamin, Nygren, Gerardo A, Gómez, Georges A, Dahourou, W Roodly, Archer, Amanda B, Payne, W Craig, Hooper, Jordan W, Tappero, Gordana, Derado, Roc, Magloire, Peter, Gerner-Smidt, Nicole, Freeman, Jacques, Boncy, Eric D, Mintz, The Cholera Serosurvey Working Group |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Population medicine.disease_cause El Tor Young Adult Cholera AJTMH and PAHO: Commemorating the 3rd Anniversary of the Cholera Outbreak in Haiti: Invited Papers Immunity Risk Factors Seroepidemiologic Studies Virology medicine Odds Ratio Humans education Child Aged Aged 80 and over education.field_of_study biology business.industry Cholera toxin Infant Odds ratio Middle Aged medicine.disease biology.organism_classification Haiti Diarrhea Infectious Diseases Child Preschool Parasitology Female medicine.symptom business |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene |
| ISSN: | 1476-1645 |
| Popis: | To assess the spectrum of illness from toxigenic Vibrio cholerae O1 and risk factors for severe cholera in Haiti, we conducted a cross-sectional survey in a rural commune with more than 21,000 residents. During March 22–April 6, 2011, we interviewed 2,622 residents ≥ 2 years of age and tested serum specimens from 2,527 (96%) participants for vibriocidal and antibodies against cholera toxin; 18% of participants reported a cholera diagnosis, 39% had vibriocidal titers ≥ 320, and 64% had vibriocidal titers ≥ 80, suggesting widespread infection. Among seropositive participants (vibriocidal titers ≥ 320), 74.5% reported no diarrhea and 9.0% had severe cholera (reported receiving intravenous fluids and overnight hospitalization). This high burden of severe cholera is likely explained by the lack of pre-existing immunity in this population, although the virulence of the atypical El Tor strain causing the epidemic and other factors might also play a role. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|