Characteristics of trabeculated myocardium burden in young and apparently healthy adults
| Autor: | Sergio Pasian, Florent Le Ven, Christian F. Deschepper, James C. Engert, Maria de la Paz Ricapito, Helena Tizón-Marcos, Olivier F. Bertrand, Eric Larose, Karine Bibeau, Swapnil Sinha, Elisabeth Bédard, Philippe Pibarot |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cardiac function curve
Adult Male medicine.medical_specialty Noncompaction cardiomyopathy Adolescent medicine.drug_class Heart Ventricles Population Diastole Magnetic Resonance Imaging Cine Enzyme-Linked Immunosorbent Assay Young Adult Reference Values Risk Factors Internal medicine Surveys and Questionnaires Natriuretic Peptide Brain medicine Natriuretic peptide Humans Heart Atria Prospective Studies Protein Precursors Prospective cohort study education education.field_of_study Ejection fraction medicine.diagnostic_test business.industry Myocardium Magnetic resonance imaging medicine.disease Myocardial Contraction Peptide Fragments Cardiology Female Cardiology and Cardiovascular Medicine business Cardiomyopathies Follow-Up Studies |
| Zdroj: | The American journal of cardiology. 114(7) |
| ISSN: | 1879-1913 |
| Popis: | Increased myocardial trabeculations define noncompaction cardiomyopathy (NCC). Imaging advancements have led to increasingly common identification of prominent trabeculations with unknown implications. We quantified and determined the impact of trabeculations' burden on cardiac function and stretch in a population of healthy young adults. One hundred adults aged 18 to 35 years (28±4 years, 55% women) without known cardiovascular disease were prospectively studied by cardiovascular magnetic resonance. Left ventricular (LV) volumes, segmental function, and ejection fraction (EF) and left atrial volumes were determined. Thickness and area of trabeculated (T) and dense (D) myocardium were measured for each standardized LV segment. N-terminal pro-brain natriuretic peptide (Nt-pro-BNP) was measured. Eighteen percent of the subjects had ≥1 positive traditional criteria for NCC, and 11% meet new proposed NCC cardiovascular magnetic resonance criteria. Trabeculated over dense myocardium ratio (T/D) ratios were uniformly greater at end-diastole versus end-systole (0.90±0.25 vs 0.42±0.13, p0.0001), in women versus men (0.85±0.24 vs 0.72±0.19, p=0.006), at anterior versus nonanterior segments (1.41±0.59 vs 0.88±0.35, p0.0001), and at apical versus nonapical segments (1.31±0.56 vs 0.87±0.38, p0.0001). The largest T/D ratios were associated with lower LVEF (57.0±5.3 vs 62±5.5, p=0.0001) and greater Nt-pro-BNP (203±98 vs 155±103, p=0.04). Multivariable regression identified greater end-systolic T/D ratios as the strongest independent predictor of lower LVEF, beyond age and gender, left atrial or LV volumes, and Nt-pro-BNP (β=-9.9, 95% CI -15 to 4.9, p0.001). In conclusion, healthy adults possess variable amounts of trabeculations that regularly meet criteria for NCC. Greater trabeculations are associated with decreased LV function. Apparently healthy young adults with increased trabecular burden possess evidence of mildly impaired cardiac function. |
| Databáze: | OpenAIRE |
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