l-Ornithine and l-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1

Autor:	Makoto Tominaga, Tsuyoshi Goto, Yee Yin Ho, Saori Akiduki, Nobuyuki Takahashi, Junya Nakato, Ryuhei Kanamoto, Kousaku Ohinata, Ryo Omae, Kunitoshi Uchida, Takafumi Mizushige, Teruo Kawada, Min-Ji Kim
Rok vydání:	2017
Předmět:	0301 basic medicine Male Ornithine medicine.medical_specialty TRPV1 Motility Down-Regulation TRPV Cation Channels Stimulation Arginine Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Membrane Transport Modulators Muscarinic acetylcholine receptor Intestine Small medicine Animals Humans Calcium Signaling Mice Knockout biology Chemistry Lysine fungi Antagonist respiratory system Ruthenium Red Mice Mutant Strains Recombinant Proteins Rats Up-Regulation Nitric oxide synthase Mice Inbred C57BL 030104 developmental biology Endocrinology HEK293 Cells biology.protein sense organs Capsaicin Capsazepine Gastrointestinal Motility 030217 neurology & neurosurgery Food Science Biotechnology
Zdroj:	Molecular nutritionfood research. 61(11)
ISSN:	1613-4133
Popis:	cope The gastrointestinal (GI) tract senses and responds to intraluminal nutrients and these interactions often affect GI functions. We found that, among basic amino acids, L-ornithine (Orn) and L-lysine (Lys) stimulated but L-arginine (Arg) suppressed GI motility after oral administration (24 mmol/kg) in mice (Orn and Lys, 14.3 and 26.4% promotion; Arg, 7.7% suppression). We investigated the mechanism of the action of Orn and Lys on GI motility. Methods and results Orn-induced promotion of small intestinal transit was significantly inhibited (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c77600a09d0a8060b1c5c5a35c0eac1 https://pubmed.ncbi.nlm.nih.gov/28722259 Zobrazit plný text záznamu Plný text