Detoxification of cadmium. Ultrastructural study and electron-probe microanalysis of the midgut in a cadmium-resistant strain of Drosophila melanogaster
| Autor: | Christiane Ballan-Dufrancais, Maurice Wegnez, Sylvie Lauverjat |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
inorganic chemicals
Drug Resistance chemistry.chemical_element digestive system General Biochemistry Genetics and Molecular Biology Biomaterials Detoxification Melanogaster Metallothionein Animals Tissue Distribution Intestinal Mucosa Cadmium biology fungi Metals and Alloys Midgut General Medicine biology.organism_classification Copper Drosophila melanogaster chemistry Biochemistry Larva Inactivation Metabolic Ultrastructure General Agricultural and Biological Sciences Electron Probe Microanalysis |
| Zdroj: | Biology of metals. 2(2) |
| ISSN: | 0933-5854 |
| Popis: | The midgut of a cadmium-resistant strain of Drosophila melanogaster has been studied at the ultrastructural level and by electron-probe microanalysis (EPMA). Chronic exposure to cadmium leads to a concentration of the metal in a lysosomal system developed in both anterior and posterior segments of the midgut, where it coexists with copper and sulfur. This mechanism apparently ensures a permanent cadmium detoxification and prevents cellular injury. Wild-type flies fed on a cadmium-contaminated medium manifest the same detoxification process. As a result of contamination, copper is stored along the entire length of the midgut, including a part of the middle-midgut previously named 'copper-accumulating region'. Our data demonstrate that the midgut, particularly the posterior segment, is an accumulative organ for both cadmium and copper. The involvement of the metallothionein system in the detoxification process is discussed. |
| Databáze: | OpenAIRE |
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