Clinical significance of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in the follow-up of colorectal cancer: searching off approaches increasing specificity for detection of recurrence
| Autor: | Huseyin San, Kursat Okuyucu, Semra Ince, Engin Alagoz, Nuri Arslan, Oğuz Hançerlioğulları |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer R895-920 Colonoscopy Standardized uptake value Malignancy 030218 nuclear medicine & medical imaging Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen 18F-fluorodeoxyglucose positron emission tomography medicine Radiology Nuclear Medicine and imaging Clinical significance medicine.diagnostic_test biology business.industry computed tomography recurrent colorectal cancer metabolic tumor markers medicine.disease Primary tumor Oncology Positron emission tomography 030220 oncology & carcinogenesis biology.protein Radiology Nuclear medicine business Research Article |
| Zdroj: | Radiology and Oncology Radiology and Oncology, Vol 51, Iss 4, Pp 378-385 (2017) |
| ISSN: | 1581-3207 |
| DOI: | 10.1515/raon-2017-0045 |
| Popis: | BackgroundNearly 40% of colorectal cancer (CRC) recurs within 2 years after resection of primary tumor. Imaging with fluorine-18-fluorodeoxyglucose (l8F-FDG) positron emission tomography/computed tomography (PET/CT) is the most recent modality and often applied for the evaluation of metastatic spread during the follow-up period. Our goal was to study the diagnostic importance of18F-FDG-PET/CT data of maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG) and the difference of SUVmax on dual-time imaging in CRC.Patients and methodsWe examined the SUVmax value of lesions on control or restaging18F-FDG-PET/CT of 53 CRC patients. All lesions with increased SUVmax values were confirmed by colonoscopy or histopathology. We compared PET/CT results with conventional imaging modalities (CT, MRI) and tumor markers (carbohydrate antigen 19-9 [Ca 19-9], carcinoembryonic antigen [CEA]).ResultsMean SUVmax was 6.9 ± 5.6 in benign group, 12.7 ± 6.1 in malignant group. Mean TLG values of malignant group and benign group were 401 and 148, respectively.18F-FDG-PET/CT was truely positive in 48% of patients with normal Ca 19-9 or CEA levels and truely negative in 10% of cases with elevated Ca 19-9 or CEA. CT or MRI detected suspicious malignancy in 32% of the patients and18F-FDG-PET/CT was truely negative in 35% of these cases. We found the most important and striking statistical difference of TLG value between the groups with benign and recurrent disease.ConclusionsAlthough SUVmax is a strong metabolic parameter (p = 0.008), TLG seems to be the best predictor in recurrence of CRC (p = 0.001); both are increasing the specificity of18F-FDG-PET/CT. |
| Databáze: | OpenAIRE |
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