Banff Histopathological Consensus Criteria for Preimplantation Kidney Biopsies
| Autor: | J. Goldberg, Y. Paliwa, Surya V. Seshan, Serena M. Bagnasco, X. Gao, D. S. R. David, C. Klein, Douglas Landsittel, Joseph P. Gaut, Agnieszka Perkowska-Ptasińska, Michael Mengel, Alton B. Farris, Maxwell L. Smith, T. Horwedel, Helen Liapis, Eva Honsova, K. L. Pegas, P. Randhawa, Mark Haas, Edward S. Kraus |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology Consensus 030232 urology & nephrology Consensus criteria 030230 surgery Interstitial fibrosis Kidney 03 medical and health sciences 0302 clinical medicine Biopsy medicine Humans Immunology and Allergy Pharmacology (medical) Kidney transplantation Transplantation Frozen section procedure medicine.diagnostic_test business.industry Arterial intimal fibrosis Biopsy Needle Glomerulosclerosis medicine.disease Kidney Transplantation Tissue Donors medicine.anatomical_structure Radiology business |
| Zdroj: | American Journal of Transplantation. 17:140-150 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/ajt.13929 |
| Popis: | The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of preimplantation kidney biopsies. Digitally scanned slides were used (i) to evaluate interobserver variability of histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue of wedge and needle core biopsies, and (ii) to correlate consensus histopathologic findings with graft outcome in a cohort of biopsies from international medical centers. Intraclass correlations (ICCs) and univariable and multivariable statistical analyses were performed. Good to fair reproducibility was observed in semiquantitative scores for percentage of glomerulosclerosis, arterial intimal fibrosis and interstitial fibrosis on frozen wedge biopsies. Evaluation of frozen wedge and core biopsies was comparable for number of glomeruli, but needle biopsies showed worse ICCs for glomerulosclerosis, interstitial fibrosis and tubular atrophy. A consensus evaluation form is provided to help standardize the reporting of histopathologic lesions in donor biopsies. It should be recognized that histologic parameters may not correlate with graft outcome in studies based on organs deemed to be acceptable after careful clinical assessment. Significant limitations remain in the assessment of implantation biopsies. |
| Databáze: | OpenAIRE |
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