Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia
| Autor: | Steven Joung, Michael J. Peek, Ron Benzie, Charles R. Mackay, Kahlia Wong, David P. Eviston, Martin O'Hely, Eliana Mariño, Mingjing Hu, Yu Anne Yap, James L. Richards, David Wilson, Ann Louise Ponsonby, Ralph Nanan, Peter Hsu, Ann Quinton, Ann P. Chidgey, Peter Vuillermin, Mimi L.K. Tang, Jane E. Dahlstrom, Brigitte Santner-Nanan, Norelle L. Daly, Laurence Macia, Fiona Collier |
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| Přispěvatelé: | Dwyer, T |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
General Physics and Astronomy 02 engineering and technology Acetates medicine.disease_cause T-Lymphocytes Regulatory Immune tolerance Mice Child Development Pre-Eclampsia Pregnancy Medicine Longitudinal Studies Prospective Studies lcsh:Science Maternal-Fetal Exchange CD4-positive T cells reproductive and urinary physiology Multidisciplinary Organ Size 021001 nanoscience & nanotechnology Autoimmune regulator medicine.anatomical_structure Child Preschool Prenatal Exposure Delayed Effects embryonic structures Female 0210 nano-technology Adult medicine.medical_specialty Regulatory T cell Offspring T cell Science chemical and pharmacologic phenomena Thymus Gland General Biochemistry Genetics and Molecular Biology Article Ultrasonography Prenatal Preeclampsia 03 medical and health sciences Young Adult Immune system Fetus Internal medicine Immune Tolerance Animals Germ-Free Life Humans business.industry Infant Newborn Infant General Chemistry Immune dysregulation Translational research medicine.disease Gastrointestinal Microbiome 030104 developmental biology Endocrinology Animals Newborn Case-Control Studies Dietary Supplements lcsh:Q business Transcription Factors |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and is linked to atopic disorders in offspring. Here we show reduction of fetal thymic size, altered thymic architecture and reduced fetal thymic regulatory T (Treg) cell output in preeclamptic pregnancies, which persists up to 4 years of age in human offspring. In germ-free mice, fetal thymic CD4+ T cell and Treg cell development are compromised, but rescued by maternal supplementation with the intestinal bacterial metabolite short chain fatty acid (SCFA) acetate, which induces upregulation of the autoimmune regulator (AIRE), known to contribute to Treg cell generation. In our human cohorts, low maternal serum acetate is associated with subsequent preeclampsia, and correlates with serum acetate in the fetus. These findings suggest a potential role of acetate in the pathogenesis of preeclampsia and immune development in offspring. Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development. |
| Databáze: | OpenAIRE |
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