Blood Transfusion, Alcohol Consumption, and Cigarette Smoking in Causation of Hepatocellular Carcinoma: A Case‐Control Study in Fukuoka, Japan
Autor: | Tomio Hirohata, Setsuko Takeshita, Keitaro Tanaka |
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Jazyk: | angličtina |
Rok vydání: | 1988 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty HBsAg Hepatitis B virus Blood transfusion Carcinoma Hepatocellular Alcohol Drinking Hepatocellular carcinoma medicine.medical_treatment medicine.disease_cause Gastroenterology Article Risk Factors Internal medicine medicine Humans Risk factor Aged Hepatitis B Surface Antigens biology business.industry Smoking Liver Neoplasms Case-control study Age Factors Transfusion Reaction Middle Aged medicine.disease biology.organism_classification Hepatitis B digestive system diseases Surgery Oncology Hepadnaviridae Relative risk Female business Alcohol |
Zdroj: | Japanese Journal of Cancer Research : Gann |
ISSN: | 1876-4673 0910-5050 |
Popis: | In the present study, we investigated the association between hepatocellular carcinoma (HCC) and hepatitis B virus infection (HBV), blood transfusion and drinking and smoking habits by comparing 124 HCC cases and 250 controls. We confirmed a very high relative risk (RR), i.e. 31.0 (P less than 0.001), among persons who were positive for serum hepatitis B surface antigen (HBsAg). However, the prevalence of serum HBsAg positives among our cases was only 21%, about half of those reported earlier, indicating a role of other etiological factors. Those who have a history of blood transfusion showed a significantly elevated RR of 3.0 (P less than 0.001) or 4.9 (P less than 0.001), and most of them (85%) were non-carriers of HBV. Thus, the past history of blood transfusion is an important risk factor among the Japanese. Unidentified non-A, non-B hepatitis viruses in transfused blood probably play a significant role in causing HCC. We estimated that 15% of male HCCs were attributable to blood transfusion. A positive relationship between alcohol consumption and HCC was detected, particularly among HBsAg-negative subjects with no history of blood transfusion who had drunk heavily in their younger years. RR estimates were not great (e.g., heavy drinkers: 2.5), but a substantial proportion of HCC may be attributed to drinking because of common drinking habits among Japanese males. Smoking was also found to have a positive association, but the relationship at a young age was less clear, and further investigation is needed to clarify the etiological role of smoking. |
Databáze: | OpenAIRE |
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