Decreases in plasma TNF-alpha level and IFN-gamma mRNA level in peripheral blood mononuclear cells (PBMC) and an increase in IL-2 mRNA level in PBMC are associated with effective highly active antiretroviral therapy in HIV-infected patients

Autor:	P. Clayette, Dominique Dormont, P. Brazille, C. Leport, Nathalie Dereuddre-Bosquet, O. Boyer, Olivier Benveniste, J.‐L. Vildé
Rok vydání:	2003
Předmět:	Adult Male Anti-HIV Agents medicine.medical_treatment Immunology HIV Infections Peripheral blood mononuclear cell Virus Immunophenotyping Interferon-gamma Immunopathology Antiretroviral Therapy Highly Active Immunology and Allergy Medicine Humans Prospective Studies RNA Messenger business.industry Tumor Necrosis Factor-alpha Original Articles Middle Aged Viral Load CD4 Lymphocyte Count Cytokine Leukocytes Mononuclear Cytokines Interleukin-2 Tumor necrosis factor alpha Female business Viral load CD8 Follow-Up Studies
Zdroj:	Clinical and experimental immunology. 131(2)
ISSN:	0009-9104
Popis:	SUMMARYIn this study, we investigated the cytokine profiles of 14 treatment-naive HIV-infected patients on the initiation of highly active antiretroviral therapy (HAART). At baseline, plasma levels of TNF-α and its mRNA in peripheral blood mononuclear cells (PBMC) were highest in the most severely immunocompromised patients (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c725ee05de2737979ce7880ea22fb87 https://pubmed.ncbi.nlm.nih.gov/12562393 Zobrazit plný text záznamu Plný text