Role of viruses in oral squamous cell carcinoma
| Autor: | Meenal Verma, Rashmi Metgud, Ashish Sharma, Madhusudan Astekar |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
squamous cell carcinoma
Oncology lcsh:Internal medicine HPV Cancer Research medicine.medical_specialty Review transforming region Bioinformatics Transforming Genes cellular proteins oncogene proteins EBV Internal medicine Genetic predisposition Medicine Basal cell lcsh:RC31-1245 Cellular proteins vaccines business.industry viral genome apoptosis lcsh:Other systems of medicine lcsh:RZ201-999 AIDS stomatognathic diseases caspases transforming genes Etiology business Oncovirus |
| Zdroj: | Oncology Reviews Oncology Reviews, Vol 6, Iss 2 (2012) |
| ISSN: | 1970-5565 1970-5557 |
| DOI: | 10.4081/oncol.2012.e21 |
| Popis: | The etiology of oral squamous cell carcinoma (OSCC) is complex and involves many factors. The most clearly defined risk factors are smoking and alcohol, which substantially increase the risk of oral SCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility and oncogenic viruses. Some viruses are strongly associated with OSCC while the association of others is less frequent and may depend on co-factors for their carcinogenic effects. Therefore, the exact role of viruses must be evaluated with care in order to improve the diagnosis and treatment of OSCC. |
| Databáze: | OpenAIRE |
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