A comparison of the efficacy and tolerability of two recombinant human follicle-stimulating hormone preparations in patients undergoing in vitro fertilization-embryo transfer
| Autor: | Ernest Loumaye, Fidelis Akagbosu, Lisa M Gibbons, Susan Lancaster, Dominique Gourdon, Patrick Engrand, Peter Brinsden |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Randomization Adolescent medicine.drug_class medicine.medical_treatment Follitropin Fertilization in Vitro Biology Buserelin Chorionic Gonadotropin Follicle-stimulating hormone Pregnancy medicine Humans Gynecology In vitro fertilisation Cumulative dose Obstetrics and Gynecology Embryo Transfer Embryo transfer Recombinant Proteins Reproductive Medicine Tolerability Glycoprotein Hormones alpha Subunit Follicle Stimulating Hormone beta Subunit Female Gonadotropin Follicle Stimulating Hormone Infertility Female |
| Zdroj: | Fertility and sterility. 73(1) |
| ISSN: | 0015-0282 |
| Popis: | Objective: To compare the efficacy and tolerability of two recombinant human FSH (r-hFSH) preparations, follitropin-α (Gonal-F; Ares Serono, Geneva, Switzerland) and follitropin-β (Puregon; Organon, Oss, the Netherlands), for superovulation in patients undergoing IVF-ET. Design: Randomized, parallel-group, assessor-blind, single-center trial. Setting: Outpatient tertiary referral center for assisted reproductive techniques. Patient(s): Forty-four infertile women undergoing IVF-ET. Intervention(s): After down-regulation with buserelin acetate, patients were randomized to receive follitropin-α or follitropin-β, 150 IU/d for 6 days; after that, dosages were adjusted according to the ovarian response. Main Outcome Measure(s): Cumulative dose of r-hFSH; duration of r-hFSH treatment; number of follicles of ≥11 mm and of 14 mm on day 7 of r-hFSH treatment and on the day of hCG administration; number of oocytes retrieved; number of viable embryos; and number of pregnancies (biochemical, ectopic, miscarried) and clinical pregnancies. Result(s): There were no statistically significant differences in any efficacy measures between the two preparations. The incidence of systemic adverse events was comparable in the two groups. Local reactions at the injection site were significantly more common and more severe with follitropin-β than with follitropin-α Conclusion(s): Follitropin-α and follitropin-β have comparable efficacy in patients undergoing IVF-ET. |
| Databáze: | OpenAIRE |
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