Implications of the magnetic susceptibility difference between grey and white matter for single-voxel proton spectroscopy at 7 T
| Autor: | Jack J.A. van Asten, David G. Norris, Jan Willem Thielen, Seyedmorteza Rohani Rankouhi, Donghyun Hong |
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| Rok vydání: | 2018 |
| Předmět: |
Nuclear and High Energy Physics
Proton Medizin Biophysics Grey matter computer.software_genre Biochemistry 150 000 MR Techniques in Brain Function 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences Laser linewidth All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Nuclear magnetic resonance Voxel 130 000 Cognitive Neurology & Memory Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15] medicine Spectroscopy Physics Chemical shift Condensed Matter Physics Magnetic susceptibility medicine.anatomical_structure computer 030217 neurology & neurosurgery |
| Zdroj: | Journal of Magnetic Resonance, 297, pp. 51-60 Journal of Magnetic Resonance, 297, 51-60 |
| ISSN: | 1090-7807 |
| Popis: | Magnetic susceptibility differences between grey matter (GM) and white matter (WM) can potentially affect lineshapes and chemical shifts in single-voxel spectroscopy. This study aimed to investigate the consequences and potential utility of these effects. Spectroscopy voxels were segmented into GM, WM, and cerebrospinal fluid based on T1-weighted images. GM and WM lineshapes were computed using multi-echo gradient-echo images to measure the frequency distribution. Twenty 7 Tesla single voxel spectra with corresponding T1-weighted images were acquired from the frontal and parietal lobes from five healthy human volunteers. Consistent frequency shifts (mean [±SD] 4.9 ± 2.0 Hz) and linewidth differences (2.4 ± 1.5 Hz) between the two tissue types were observed. Directly visible metabolites (creatine, choline, and myo-inositol) exhibited frequency shifts and linewidth differences that were consistent with a linear-weighted summation of their expected GM and WM distribution ratios. The magnetic susceptibility difference between GM and WM had a detectable effect on single-voxel proton spectra, which results in both frequency shifts and lineshape broadening. This effect can be used to estimate the relative metabolic distribution in the GM and WM for directly observable metabolites. Fractional distributions estimated with this method demonstrated good agreement with literature values for the selected metabolites. |
| Databáze: | OpenAIRE |
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