Effect of antiprogestins and tamoxifen on growh inhibition of MCF-7 human breast cancer cells in nude mice
| Autor: | Yayun Liang, El Etreby Mf |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
medicine.medical_specialty Antineoplastic Agents Hormonal medicine.drug_class Mice Nude Breast Neoplasms Gonanes Mice chemistry.chemical_compound Hormone Antagonists Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols Tumor Cells Cultured medicine Animals Humans skin and connective tissue diseases business.industry Mifepristone Antiestrogen medicine.disease Tamoxifen Endocrinology Receptors Estrogen Oncology MCF-7 chemistry Tumor progression Estrogen Cancer research Female Growth inhibition Receptors Progesterone business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Breast Cancer Research and Treatment. 49:109-117 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1023/a:1006098910000 |
| Popis: | This is the first report demonstrating an in vivo antitumor activity of antiprogestins (mifepristone, onapristone) alone and in combination with tamoxifen in the MCF-7 human breast cancer model. The MCF-7 cells produced progressive growing tumors in female nude mice supplemented with 17beta-estradiol. Tumor regression was observed following either estrogen ablation alone or estrogen ablation in combination with tamoxifen. Monotherapy with tamoxifen or antiprogestins caused a retardation of estrogen-induced tumor progression. Complete inhibition or prevention of tumor growth occurred as a result of simultaneous administration of mifepristone and tamoxifen. The addition of mifepristone in this combination treatment was also effective in delaying or preventing tumor escape (relapse) from the antiestrogenic (antitumor) effect of tamoxifen. These results suggest a potential clinical benefit of adding an antiprogestin to antiestrogen therapy of breast cancer patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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