Blood clearances of 99mTc-phytate and indocyanine green in carbon tetrachloride treated dogs
| Autor: | Hiroshi Shibata, Naoya Odani |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Indocyanine Green
Male medicine.medical_specialty genetic structures Phytic Acid Bilirubin Metabolic Clearance Rate Urology CCL4 Toxicology digestive system chemistry.chemical_compound Dogs Internal medicine medicine Carnivora Animals Aspartate Aminotransferases Carbon Tetrachloride biology Chemistry Fissipedia Alanine Transaminase Organotechnetium Compounds biology.organism_classification eye diseases Endocrinology Carbon tetrachloride Female Liver function Hepatic dysfunction Indocyanine green |
| Zdroj: | The Journal of toxicological sciences. 16(4) |
| ISSN: | 0388-1350 |
| Popis: | The comparative study of the blood clearances of 99mTc-phytate (99mTc-P) and indocyanine green (ICG) was carried out in dogs with hepatic injury induced by carbon tetrachloride (CCl4), and the blood clearance of 99mTc-P or ICG was compared with the levels of serum transaminase and bilirubin. The blood clearances of 99mTc-P and ICG in dogs decreased with increase in doses of CCl4 and with elapsed time after CCl4 administration. The decreases were correspondent to the increase in serum transaminase activity and bilirubin level. The blood clearance test of 99mTc-P in dogs showed a equal degree of sensitivity and a higher degree of accuracy for the acute hepatic dysfunction induced by CCl4 as compared with the blood clearance test of ICG. |
| Databáze: | OpenAIRE |
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