Schizophrenia and sudden cardiac death—A review

Autor:	M.J. Pekka Raatikainen, Kaisa Saari, Heikki V. Huikuri, Markku J. Savolainen, Matti Isohanni, Antti Alaräisänen, Olavi Pelkonen, Hannu Koponen
Rok vydání:	2008
Předmět:	medicine.medical_specialty Long QT syndrome Population Torsades de pointes Disease Sudden death Sudden cardiac death Risk Factors medicine Humans Obesity Psychiatry education Life Style education.field_of_study business.industry Mortality rate Smoking Arrhythmias Cardiac medicine.disease Diet Long QT Syndrome Psychiatry and Mental health Death Sudden Cardiac Schizophrenia business Antipsychotic Agents
Zdroj:	Nordic Journal of Psychiatry. 62:342-345
ISSN:	1502-4725 0803-9488
DOI:	10.1080/08039480801959323
Popis:	Schizophrenia is a devastating mental disorder, which is often associated with severe loss of functioning and shortened life expectancy. Suicides and accidents are well-known causes of the excess mortality, but patients with schizophrenia have also been reported to be three times as likely to experience sudden unexpected death as individuals from the general population. This review is aimed to offer an update of the prevalence and mechanisms for sudden cardiac death in schizophrenia. The PubMed database was searched from 1966 up to May 2007 with key words schizophrenia AND " sudden cardiac death" OR "autonomic dysfunction" OR "torsades de pointes". Part of the high death rates may be explained by long-lasting negative health habits, disease- and treatment-related metabolic disorders, and consequent increased frequencies of cardiovascular diseases. The antipsychotic medications may also increase the risk as some antipsychotics may cause prolongation of QT-time, serious ventricular arrhythmias and predispose to sudden death. Autonomic dysfunction seen as low heart rate variability and decreased baroreflex sensitivity may also contribute via malignant arrhythmias. Due to the complex interaction of various risk factors for sudden death, the patients need a comprehensive follow-up of their physical health. In addition, more studies on the role and prevalence of autonomic dysfunction in psychotic patients are needed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6e9cba2f1058e31a91fbbc8c04841d https://doi.org/10.1080/08039480801959323 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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