Regioselective Formation of 5-Methylene-6-methoxy-1,4,5,6-tetrahydropyridazines from the [4+2]-Cycloaddition Reaction of In Situ Generated 1,2-Diaza-1,3-dienes with Methoxyallene

Autor:	Simona Nicolini, Fabio Mantellini, Giada Moscatelli, Gianfranco Favi, Orazio A. Attanasi, Serena Mantenuto
Rok vydání:	2014
Předmět:	In situ chemistry.chemical_compound Chemistry Organic Chemistry Regioselectivity Methylene Brønsted–Lowry acid–base theory Combinatorial chemistry Cycloaddition
Zdroj:	Synlett. 26:193-196
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0034-1379550
Popis:	A regioselective inverse-electron-demand hetero-Diels–­Alder reaction of in situ generated 1,2-diaza-1,3-dienes with methoxyallene is reported. These Lewis and Bronsted acid free reactions benefit from operational simplicity and allow access to synthetically valuable 5-methylene-6-methoxy-1,4,5,6-tetrahydropyridazines in high yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6e709117b37a323fc10891fc2fa7c5 https://doi.org/10.1055/s-0034-1379550 Zobrazit plný text záznamu