Bidirectional association between atopic dermatitis, conjunctivitis, and other ocular surface diseases: A systematic review and meta-analysis
| Autor: | Alexander Egeberg, Tine A. Christensen, Jacob P. Thyssen, Zohra F. Ahmadzay, Anne-Sofie Halling, Steffen Heegaard, Pernille Rævdal, Miriam Kolko, Nicolai Loft, Henrik H.P. Larsen, Nina Haarup Ravn, Jonathan I. Silverberg |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Eye Diseases business.industry Dermatology Atopic dermatitis Disease Odds ratio medicine.disease Conjunctivitis Comorbidity Confidence interval Dermatitis Atopic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Meta-analysis medicine Humans SCORAD business Blepharitis |
| Zdroj: | Journal of the American Academy of Dermatology. 85(2) |
| ISSN: | 1097-6787 |
| Popis: | Background Conjunctivitis and several other ocular surface diseases (OSDs) have been linked to atopic dermatitis (AD) and its treatment. Objectives To examine the association between AD, conjunctivitis, and other OSDs. Methods A systematic review and meta-analysis was performed. Two authors independently searched EMBASE, PubMed, SCOPUS, and Web of Science and performed title/abstract and full-text review and data abstraction. Pooled random-effects prevalence and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. Results The search yielded 5719 nonduplicate articles; 134 were included in the quantitative analysis. AD was associated with conjunctivitis compared to reference individuals (OR, 2.78; 95% CI, 2.33-3.32); the prevalences of conjunctivitis in patients with AD and reference individuals were 31.7% (95% CI, 27.7-35.9) and 13.3% (95% CI, 11.0-15.7), respectively. Keratoconus (OR, 3.71; 95% CI, 1.99-6.94) and ocular herpes simplex (OR, 3.65; 95% CI 2.04-6.51) were also associated with AD. Limitations Disease definitions differed and often relied on self-reports. Few studies provided data concerning AD phenotype or OSDs other than conjunctivitis. Conclusions Conjunctivitis is the most common ocular comorbidity in AD. Signs and symptoms of conjunctivitis and other OSDs in AD may be underreported, making proactive inquiry and examination by physicians treating patients with AD important. |
| Databáze: | OpenAIRE |
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