The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma
| Autor: | Lorenz Kadletz-Wanke, Faris F. Brkic, Gregor Heiduschka, Tobias Maier, Stefan Stoiber, Marlene Friedl |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adenoid cystic carcinoma Lymphocyte Medicine (miscellaneous) fibrinogen-to-lymphocyte ratio Fibrinogen Gastroenterology survival Article Internal medicine medicine Carcinoma Head and neck business.industry Cancer adenoid-cystic carcinoma medicine.disease Confidence interval medicine.anatomical_structure Cohort outcome Medicine business prognostic marker medicine.drug |
| Zdroj: | Journal of Personalized Medicine, Vol 11, Iss 1228, p 1228 (2021) Journal of Personalized Medicine Volume 11 Issue 11 |
| ISSN: | 2075-4426 |
| Popis: | Many patients with adenoid-cystic carcinoma (ACC) experience an indolent course of disease over many years but face late recurrence, and long-term survivors are rare. Due to its infrequent occurrence, it is hard to predict outcome in these patients. The fibrinogen-to-lymphocyte ratio (FLR) was recently proposed as an outcome prognosticator in different cancer entities. We aimed to investigate its prognostic relevance in patients with head and neck ACC. This retrospective analysis was performed including all patients treated for ACC between 1998 and 2020. The FLR ratio was calculated based on pretreatment values (0–7 days). The study cohort was dichotomized based on optimized threshold value and compared for differences in outcome (overall survival (OS) and disease-free survival (DFS)). In the cohort of 39 included patients, the OS was significantly longer in the low (n = 28) compared to the high pretreatment FLR group (n = 11) (median OS 150.5 months, 95% confidence intervals (CI) 85.3–215.7 months vs. 29.4 months, 95% CI not reached p = 0.0093). Similarly, the DFS was significantly longer in the low FLR group (median DFS 74.5 months, 95% CI 30.6–118.4 months vs. 11.0 months, 95% CI 5.1–16.9 months p = 0.019). The FLR is an easily obtainable and simple marker and may be a valuable outcome prognosticator in patients with ACC. Further studies are needed for validation of our results. |
| Databáze: | OpenAIRE |
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