Serum Vitamin D Level is Inversely Associated With Anti-Cyclic Citrullinated Peptide Antibody Level and Disease Activity in Rheumatoid Arthritis Patients
| Autor: | Yanan Wang, Long Cai, Shanshan Wang, Hongjuan Zhou, Huaping Shi, Xuechai Shang, Fengwei Zhang, Siyuna Luo |
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| Rok vydání: | 2016 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine medicine.medical_specialty biology medicine.diagnostic_test business.industry medicine.disease Article vitamin D deficiency Disease activity 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Serum vitamin D level Rheumatology Rheumatoid arthritis Internal medicine Erythrocyte sedimentation rate Cohort medicine biology.protein Vitamin D and neurology Antibody business |
| Zdroj: | Archives of Rheumatology. 31:64-70 |
| ISSN: | 2148-5046 |
| Popis: | Objectives: This study aims to assess the relationship between serum vitamin D and anti-cyclic citrullinated peptide (anti-CCP) antibody levels, as well as disease activity in patients with newly diagnosed rheumatoid arthritis (RA). Patients and methods: These measurements were conducted between January 2014 and June 2014. Serum 25-hydroxy vitamin D (25-OH-D), anti-CCP antibody, and erythrocyte sedimentation rates were measured in a cohort of 154 patients (66 males, 88 females; mean age 53.5±12.4; range 29 to 79 years) with early RA. A control group of 60 healthy participants (25 males, 35 females; mean age 51.4±10.3; range 25 to 75 years) was only evaluated for serum 25-OH-D levels. Disease activity was measured by calculating the 28-Joint Disease Activity Score. Blood samples were drawn from cubital veins. After centrifugation, serum was collected and stored under minus 20 degrees. Results: Vitamin D deficiency was more prevalent in RA group compared with control group (48.70% vs. 30.00%, p |
| Databáze: | OpenAIRE |
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