Impairments in gait kinematics and postural control may not correlate with dopamine transporter depletion in individuals with mild to moderate Parkinson's disease
| Autor: | Fernanda Cechetti, Aline Souza Pagnussat, Luis Henrique Tieppo Fornari, Neivo da Silva Junior, Brenda Tubelo Pereira, Giulia Palermo Schifino, Maria Eduarda Parcianello Cabeleira, Alexandre Severo do Pinho, Philipe Souza Corrêa, Ane Caroline Dotta Asquidamini, Carlos Roberto de Mello Rieder, Ariane Bolla Freire |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Levodopa medicine.medical_specialty Parkinson's disease Severity of Illness Index 03 medical and health sciences chemistry.chemical_compound Imaging Three-Dimensional Spatio-Temporal Analysis 0302 clinical medicine Physical medicine and rehabilitation Dopamine medicine Postural Balance Humans Neurotransmitter Gait 030304 developmental biology Dopamine transporter Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins 0303 health sciences biology business.industry General Neuroscience Dopaminergic Brain Parkinson Disease Middle Aged medicine.disease Biomechanical Phenomena Cross-Sectional Studies chemistry biology.protein Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Neuroscience. 49:1640-1648 |
| ISSN: | 1460-9568 0953-816X |
| Popis: | Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the loss of dopamine, an important neurotransmitter involved in regulating movement. Nuclear medicine imaging methods such as single-photon emission computed tomography (SPECT) combined with radiotracers can obtain the density of this neurotransmitter. This reduced density leads to classic PD symptoms, such as bradykinesia, tremor and stiffness, consequently affecting walking and postural control. The aim of this study was to verify the correlation between disorders of gait kinematics and postural instability with dopamine depletion in individuals with mild to moderate PD. This is a descriptive, observational cross-sectional study. Subjects were assessed for spatiotemporal gait parameters by a three-dimensional motion capture system, for postural control by stabilometry on a force plate. Dopamine depletion was verified through 99mTc-TRODAT-1 (SPECT-CT) examination. The subjects were in the off-stage of levodopa in all analysis. We evaluated 71 individuals, 32 with mild to moderate PD (HY 2 and 2.5) and 39 healthy individuals matched for gender, age, and height. There was a significant difference between the groups regarding the spatiotemporal variables of gait, as well as in the stabilometric variables. However, there was no correlation between these disturbances and the uptake values of 99mTc-TRODAT-1. The results indicate that there is no correlation between gait impairments and postural instability of individuals with mild to moderate PD and the dopaminergic depletion measured through the 99mTc-TRODAT-1 (SPECT-CT). |
| Databáze: | OpenAIRE |
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