A crystallographic map of the transition from B-DNA to A-DNA
| Autor: | Jeffrey M. Vargason, P. Shing Ho, Keith Henderson |
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| Rok vydání: | 2001 |
| Předmět: |
Models
Molecular Multidisciplinary Base Sequence Transition (genetics) Stereochemistry Sequence (biology) Context (language use) DNA Crystallography X-Ray Kinetics Structure-Activity Relationship chemistry.chemical_compound Crystallography Composite structure Oligodeoxyribonucleotides chemistry Commentary Nucleic Acid Conformation A-DNA Cytosine |
| Zdroj: | Proceedings of the National Academy of Sciences. 98:7265-7270 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.121176898 |
| Popis: | The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC) 2 , with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway. |
| Databáze: | OpenAIRE |
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