Spectroscopic characterisation of carotid atherosclerotic plaque by laser induced fluorescence
| Autor: | Alexander A. Serafetinides, Panayotis Demakakos, Agathi Paphiti, Mersini I. Makropoulou, Basil Arapoglou, Nicoletta Anastassopoulou |
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| Rok vydání: | 2001 |
| Předmět: |
Carotid Artery Diseases
Chemistry medicine.medical_treatment Lasers Krypton Fluorescence spectrometry Analytical chemistry chemistry.chemical_element Dermatology Carotid endarterectomy Laser Intracranial Arteriosclerosis Fluorescence law.invention Nuclear magnetic resonance Carotid Arteries Microscopy Fluorescence law medicine Humans Surgery Nitrogen laser Spectroscopy Laser-induced fluorescence |
| Zdroj: | Lasers in surgery and medicine. 28(1) |
| ISSN: | 0196-8092 |
| Popis: | Background and Objective: An effort has been made to distinguish the composition of carotid atherosclerotic plaques (CAP) from patients undergoing carotid endarterectomy, by laser induced fluorescence spectroscopy. Study Design/Materials and Methods: Different excitation wavelengths were used: 476, 488, and 458 nm of a continuous wave krypton/argon ion laser, and 337 nm of a pulsed nitrogen laser. Twenty-three CAP samples from different patients were investigated and several spectra from each plaque were obtained. Results: Results were crossed-examined with conventional histologic techniques, which showed three areas of different composition on the pathologic samples: fibrous tissue, lipid constituents, and calcified plaque. Gaussian fittings were performed to reproduce the fluorescence spectra as a correlation of multiple Gaussian curves. Conclusion: The accuracy for discrimination of the heterogeneous composition of the atherosclerotic plaque is still limited, due to superposition of the fluorescence emission of various plaque components. Lasers Surg. Med. 28: 67-73, 2001. |
| Databáze: | OpenAIRE |
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