Impact of Prehypertension on Common Carotid Artery Intima-Media Thickness and Left Ventricular Mass
| Autor: | Kimon Stamatelopoulos, Konstantinos Vemmos, Eleni Koroboki, Efstathios Manios, S. T. Toumanidis, Elefterios Stamboulis, Christos Papamichael, Georgios Tsivgoulis, Nikolaos Zakopoulos |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Ambulatory blood pressure Adolescent Carotid Artery Common Blood Pressure Prehypertension Young Adult medicine.artery Internal medicine medicine Humans Common carotid artery Stroke Aged Advanced and Specialized Nursing Vascular disease business.industry Middle Aged medicine.disease Surgery Blood pressure medicine.anatomical_structure Intima-media thickness Echocardiography Hypertension Cardiology Female Hypertrophy Left Ventricular Neurology (clinical) Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Stroke. 40:1515-1518 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/strokeaha.108.528174 |
| Popis: | Background and Purpose— Prehypertension has been recently introduced by JNC 7 as a new blood pressure (BP) category, associated with increased target-organ damage. Subclinical atherosclerosis by means of common artery intima-media thickness (CCA-IMT) has been incompletely investigated in prehypertensive patients. The aim of our study was to assess the extent of CCA-IMT and left ventricular mass (LVM) in prehypertensive adults in comparison to normotensive and untreated hypertensive subjects. Methods— From a total of 5221 consecutive patients screened to our Hypertension Unit we selected 896 consecutive individuals according to prespecified inclusion criteria, who underwent 24-hour ambulatory BP monitoring, carotid artery ultrasonographic, and echocardiographic measurements. Patients who received antihypertensive treatment during the BP monitoring were excluded. According to the office BP levels, patients were divided into 3 subgroups: normotensives (office BP 2 test, and ANCOVA. Results— According to the office BP levels, the distribution of the study population was: normotensives (14.4%), prehypertensives (23.7%), and hypertensives (61.9%). Prehypertensive patients had higher CCA-IMT ( P =0.038) and LVM ( P =0.030) values than normotensive subjects, even after adjustment for baseline characteristics. Greater CCA-IMT values were observed in hypertensive patients in comparison to prehypertensives ( P =0.002). Conclusions— Prehypertensive patients had higher CCA-IMT and LVM than their normotensive counterparts. Prehypertension status is cross-sectionally associated with subclinical atherosclerosis and target-organ damage. |
| Databáze: | OpenAIRE |
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