Human immunodeficiency virus-associated thrombocytopenia: Profiling hematological changes in the human immunodeficiency virus-infected and AIDS patients
| Autor: | Unnati Pitale, Manish Verma, Humera Ayesha, Pritish Chandra Pal, Deivanayagi Muthusamy, Kalyan Murru, Abhishek Singh Nayyar, M. V. R. Ratnam |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Aids patients human immunodeficiency virus biology business.industry lcsh:R CD4 cell counts Human immunodeficiency virus (HIV) complete blood picture lcsh:Medicine biology.organism_classification medicine.disease medicine.disease_cause Group A Group B Acquired immunodeficiency syndrome Immune system Retrovirus Acquired immunodeficiency syndrome (AIDS) Internal medicine medicine Cd4 cell count business |
| Zdroj: | Indian Journal of Health Sciences and Biomedical Research KLEU, Vol 11, Iss 3, Pp 234-242 (2018) |
| ISSN: | 2542-6214 |
| Popis: | CONTEXT AND AIM: AIDS is an acronym for acquired immunodeficiency syndrome caused by a retrovirus known as human immunodeficiency virus (HIV) which breaks down the body's immune system, leaving the patient vulnerable to a host of life-threatening opportunistic infections, neurological disorders, or unusual malignancies. According to estimates by the WHO and UNAIDS, 35 million people were living with HIV globally at the end of the year 2013. The first AIDS case in India was detected in the year 1986. Seldom studies have been conducted correlating CD4 cell counts and complete blood picture including platelet counts in HIV infected and AIDS patients in the Indian population. The present study was carried-out with the same intent to evaluate the CD4 cell counts and complete blood picture in the HIV infected and AIDS patients and correlate them with the sero-negative controls. MATERIALS AND METHODS: The present study was a cross-sectional, hospital-based study on patients that were divided into three groups: Group A consisting of 500 patients who were healthy controls without any systemic illness, Group B consisting of 500 patients who were diagnosed as HIV infected, and Group C consisting of 500 patients diagnosed as AIDS patients depending on their CD4 cell counts. Evaluation of complete blood picture was done using Sysmex XP 100, a fully automated analyzer, while CD4 cell counts were evaluated using Partec Cyflow Cell Counter. STATISTICAL ANALYSIS USED: The data was analyzed using SPSS version 15.0 (SPSS Inc., Chicago, IL, USA). Comparison of the said parameters was done using Analysis of Variance (ANOVA) and post-hoc Games-Howell test. P-value of |
| Databáze: | OpenAIRE |
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