Neuronal substrates of sleep homeostasis; lessons from flies, rats and mice
| Autor: | Ronald Szymusiak, Noor Alam, Jeffrey M. Donlea |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Neurons
0301 basic medicine Basal forebrain Adenosine Homeostat General Neuroscience Nucleus accumbens Biology 03 medical and health sciences Adenosine A1 receptor 030104 developmental biology 0302 clinical medicine nervous system Hypothalamus medicine Animals Homeostasis Wakefulness Sleep Neuroscience of sleep Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Current Opinion in Neurobiology. 44:228-235 |
| ISSN: | 0959-4388 |
| Popis: | Sleep homeostasis is a fundamental property of vigilance state regulation that is highly conserved across species. Neuronal systems and circuits that underlie sleep homeostasis are not well understood. In Drosophila, a neuronal circuit involving neurons in the ellipsoid body and in the dorsal Fan-shaped body is a candidate for both tracing sleep need during waking and translating it to increased sleep drive and expression. Sleep homeostasis in rats and mice involves multiple neuromodulators acting on multiple wake- and sleep-promoting neuronal systems. A functional central homeostat emerges from A1 receptor mediated actions of adenosine on wake-promoting neurons in the basal forebrain and hypothalamus, and A2A adenosine receptor-mediated actions on sleep-promoting neurons in the preoptic hypothalamus and nucleus accumbens. |
| Databáze: | OpenAIRE |
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