Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 inC. elegansembryogenesis
| Autor: | Lois G. Edgar, Barbara Robertson, Meera V. Sundaram, Queta Boese, William B. Wood, Kimberly Van Auken, Daniel C. Weaver, Tassa K Saldi, Monica Lee, Ulrich Elling |
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| Rok vydání: | 2002 |
| Předmět: |
Embryo
Nonmammalian animal structures Molecular Sequence Data Biology Homologous chromosome Animals Drosophila Proteins Amino Acid Sequence Caenorhabditis elegans Caenorhabditis elegans Proteins Myeloid Ecotropic Viral Integration Site 1 Protein Hox gene Fetal Death Molecular Biology Transcription factor Gene Homeodomain Proteins Genetics Sequence Homology Amino Acid fungi Embryogenesis Gene Expression Regulation Developmental Embryo Helminth Proteins Phenotype Neoplasm Proteins Alternative Splicing Multigene Family Mutation embryonic structures Homeobox Transcription Factors Developmental Biology |
| Zdroj: | Development. 129:5255-5268 |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.129.22.5255 |
| Popis: | Co-factor homeodomain proteins such as Drosophila Homothorax (Hth)and Extradenticle (Exd) and their respective vertebrate homologs, the Meis/Prep and Pbx proteins, can increase the DNA-binding specificity of Hox protein transcription factors and appear to be required for many of their developmental functions. We show that the unc-62 gene encodes theC. elegans ortholog of Hth, and that maternal-effect unc-62mutations can cause severe posterior disorganization during embryogenesis (Nob phenotype), superficially similar to that seen in embryos lacking function of either the two posterior-group Hox genes nob-1 and php-3 or the caudal homolog pal-1. Other zygotically actingunc-62 alleles cause earlier embryonic arrest or incompletely penetrant larval lethality with variable morphogenetic defects among the survivors, suggesting that unc-62 functions are required at several stages of development. The differential accumulation of four unc-62transcripts is consistent with multiple functions. The C. elegans exdhomologs ceh-20 and ceh-40 interact genetically withunc-62 and may have overlapping roles in embryogenesis: neither CEH-20 nor CEH-40 appears to be required when the other is present, but loss of both functions causes incompletely penetrant embryonic lethality in the presence of unc-62(+) and complete embryonic lethality in the presence of an unc-62 hypomorphic allele. |
| Databáze: | OpenAIRE |
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