Successful combined therapy with Glucantime™ and pentoxifylline for the nasal mucosal lesion recently developed in a leishmaniasis patient having untreated cutaneous lesion for seven decades
| Autor: | Thaís Gomes Verzignassi Silveira, Kárin Rosi Reinhold de Castro, Aline Ávila Brustolin, Camila Alves Mota, Sandra Marisa Pelloso, Áquila Carolina Fernandes Herculano Ramos-Milaré |
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| Rok vydání: | 2021 |
| Předmět: |
Leishmaniasis
Mucocutaneous medicine.medical_specialty Meglumine antimoniate Pentoxifylline Throat medicine Humans Nose Aged Leishmania Meglumine Antimoniate biology business.industry Mucosal lesion Cutaneous lesion Leishmaniasis medicine.disease biology.organism_classification Trypanocidal Agents Dermatology Infectious Diseases medicine.anatomical_structure Drug Therapy Combination Female Parasitology business Brazil medicine.drug |
| Zdroj: | Parasitology International. 85:102422 |
| ISSN: | 1383-5769 |
| DOI: | 10.1016/j.parint.2021.102422 |
| Popis: | Leishmaniasis is a worldwide problem and has been neglected in a wide range of fields, from diagnosis to treatment. This report describes a case of mucosal leishmaniasis, which may developped after seven decades of an inadequately treated cutaneous lesion. A female patient, 79 years old, from the non-endemic area for leishmaniasis in northern Parana, presenting mucosal lesion in the nose and throat, reported an “angry ulcer” treated inappropriately as a child when she lived in an endemic region of the state of Sao Paulo. Indirect immunofluorescence and direct parasite screening were positive. Polymerase chain reaction detected a parasite belonging to the subgenus Leishmania (Viannia) sp. Due to patients limitations, such as low weight and advanced age, the therapeutic model adopted was the combined small doses of Glucantime™ to pentoxifylline, which ensured treatment success. |
| Databáze: | OpenAIRE |
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